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cation channel, sperm associated 3
External IDs OMIM609120 MGI1924106 HomoloGene12658 IUPHAR: 390 GeneCards: CATSPER3 Gene
Species Human Mouse
Entrez 347732 76856
Ensembl ENSG00000152705 ENSMUSG00000021499
UniProt Q86XQ3 Q80W99
RefSeq (mRNA) NM_178019 NM_029772
RefSeq (protein) NP_821138 NP_084048
Location (UCSC) Chr 5:
134.33 – 134.38 Mb
Chr 13:
55.89 – 55.91 Mb
PubMed search [1] [2]

CatSper3, is a protein which in humans is encoded by the CATSPER3 gene.[1][2][3][4] CatSper3 is a member of the cation channels of sperm family of proteins. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[5]


  1. ^ Arias JM, Murbartián J, Perez-Reyes E (March 2003). "Cloning of a novel one-repeat calcium channel-like gene". Biochem. Biophys. Res. Commun. 303 (1): 31–6. doi:10.1016/S0006-291X(03)00276-6. PMID 12646162. 
  2. ^ Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: Characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC 184451. PMID 12932298. 
  3. ^ Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L et al. (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895. PMID 17227845. 
  4. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. 
  5. ^ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.