Catenin (cadherin-associated protein), alpha 1

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Catenin (cadherin-associated protein), alpha 1, 102kDa
Protein CTNNA1 PDB 1dov.png
PDB rendering based on 1dov.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CTNNA1 ; CAP102
External IDs OMIM116805 MGI88274 HomoloGene1433 GeneCards: CTNNA1 Gene
RNA expression pattern
PBB GE CTNNA1 200764 s at tn.png
PBB GE CTNNA1 200765 x at tn.png
PBB GE CTNNA1 210844 x at tn.png
More reference expression data
Species Human Mouse
Entrez 1495 12385
Ensembl ENSG00000044115 ENSMUSG00000037815
UniProt P35221 P26231
RefSeq (mRNA) NM_001290307 NM_009818
RefSeq (protein) NP_001277236 NP_033948
Location (UCSC) Chr 5:
137.95 – 138.27 Mb
Chr 18:
35.12 – 35.25 Mb
PubMed search [1] [2]

Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene.[1][2]


Catenin (cadherin-associated protein), alpha 1 has been shown to interact with Beta-catenin,[3][4][5][6][7] Plakoglobin,[4][8][9] VE-cadherin,[10][11] CDH1,[12][13][14][15][16] CDH2,[17][18] CDH3[16][19] and APC.[20][21]

See also[edit]


  1. ^ Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (November 1991). "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue". Proc Natl Acad Sci U S A 88 (20): 9156–60. doi:10.1073/pnas.88.20.9156. PMC 52671. PMID 1924379. 
  2. ^ "Entrez Gene: CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa". 
  3. ^ Oyama, T; Kanai Y; Ochiai A; Akimoto S; Oda T; Yanagihara K; Nagafuchi A; Tsukita S; Shibamoto S; Ito F (December 1994). "A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines". Cancer Res. (UNITED STATES) 54 (23): 6282–7. ISSN 0008-5472. PMID 7954478. 
  4. ^ a b Roe, S; Koslov E R; Rimm D L (June 1998). "A mutation in alpha-catenin disrupts adhesion in clone A cells without perturbing its actin and beta-catenin binding activity". Cell Adhes. Commun. (SWITZERLAND) 5 (4): 283–96. doi:10.3109/15419069809040298. ISSN 1061-5385. PMID 9762469. 
  5. ^ Piedra, Jose; Miravet Susana; Castaño Julio; Pálmer Héctor G; Heisterkamp Nora; García de Herreros Antonio; Duñach Mireia (April 2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. (United States) 23 (7): 2287–97. doi:10.1128/MCB.23.7.2287-2297.2003. ISSN 0270-7306. PMC 150740. PMID 12640114. 
  6. ^ Aberle, H; Butz S; Stappert J; Weissig H; Kemler R; Hoschuetzky H (December 1994). "Assembly of the cadherin-catenin complex in vitro with recombinant proteins". J. Cell. Sci. (ENGLAND) 107 (12): 3655–63. ISSN 0021-9533. PMID 7706414. 
  7. ^ Reuver, S M; Garner C C (April 1998). "E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton". J. Cell. Sci. (ENGLAND) 111 (8): 1071–80. ISSN 0021-9533. PMID 9512503. 
  8. ^ Sacco, P A; McGranahan T M; Wheelock M J; Johnson K R (August 1995). "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin". J. Biol. Chem. (UNITED STATES) 270 (34): 20201–6. doi:10.1074/jbc.270.34.20201. ISSN 0021-9258. PMID 7650039. 
  9. ^ Obama, H; Ozawa M (April 1997). "Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin)". J. Biol. Chem. (UNITED STATES) 272 (17): 11017–20. doi:10.1074/jbc.272.17.11017. ISSN 0021-9258. PMID 9110993. 
  10. ^ Lewalle, J M; Bajou K; Desreux J; Mareel M; Dejana E; Noël A; Foidart J M (December 1997). "Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro". Exp. Cell Res. (UNITED STATES) 237 (2): 347–56. doi:10.1006/excr.1997.3799. ISSN 0014-4827. PMID 9434630. 
  11. ^ Shasby, D Michael; Ries Dana R; Shasby Sandra S; Winter Michael C (June 2002). "Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin". Am. J. Physiol. Lung Cell Mol. Physiol. (United States) 282 (6): L1330–8. doi:10.1152/ajplung.00329.2001. ISSN 1040-0605. PMID 12003790. 
  12. ^ Kinch, M S; Clark G J; Der C J; Burridge K (July 1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. (UNITED STATES) 130 (2): 461–71. doi:10.1083/jcb.130.2.461. ISSN 0021-9525. PMC 2199929. PMID 7542250. 
  13. ^ Oneyama, Chitose; Nakano Hirofumi; Sharma Sreenath V (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug". Oncogene (England) 21 (13): 2037–50. doi:10.1038/sj.onc.1205271. ISSN 0950-9232. PMID 11960376. 
  14. ^ Navarro, P; Lozano E; Cano A (August 1993). "Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin". J. Cell. Sci. (ENGLAND) 105 (4): 923–34. ISSN 0021-9533. PMID 8227214. 
  15. ^ Takahashi, K; Suzuki K; Tsukatani Y (July 1997). "Induction of tyrosine phosphorylation and association of beta-catenin with EGF receptor upon tryptic digestion of quiescent cells at confluence". Oncogene (ENGLAND) 15 (1): 71–8. doi:10.1038/sj.onc.1201160. ISSN 0950-9232. PMID 9233779. 
  16. ^ a b Schmeiser, K; Grand R J (April 1999). "The fate of E- and P-cadherin during the early stages of apoptosis". Cell Death Differ. (ENGLAND) 6 (4): 377–86. doi:10.1038/sj.cdd.4400504. ISSN 1350-9047. PMID 10381631. 
  17. ^ Straub, Beate K; Boda Judit; Kuhn Caecilia; Schnoelzer Martina; Korf Ulrike; Kempf Tore; Spring Herbert; Hatzfeld Mechthild; Franke Werner W (December 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell. Sci. (England) 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. ISSN 0021-9533. PMID 14625392. 
  18. ^ Wahl, James K; Kim Young J; Cullen Janet M; Johnson Keith R; Wheelock Margaret J (May 2003). "N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane". J. Biol. Chem. (United States) 278 (19): 17269–76. doi:10.1074/jbc.M211452200. ISSN 0021-9258. PMID 12604612. 
  19. ^ Klingelhöfer, J; Troyanovsky R B; Laur O Y; Troyanovsky S (August 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". J. Cell. Sci. (ENGLAND) 113 (16): 2829–36. ISSN 0021-9533. PMID 10910767. 
  20. ^ Su, L K; Vogelstein B; Kinzler K W (December 1993). "Association of the APC tumor suppressor protein with catenins". Science (UNITED STATES) 262 (5140): 1734–7. doi:10.1126/science.8259519. ISSN 0036-8075. PMID 8259519. 
  21. ^ Daniel, J M; Reynolds A B (September 1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. (UNITED STATES) 15 (9): 4819–24. ISSN 0270-7306. PMC 230726. PMID 7651399. 

Further reading[edit]