Cathepsin L2

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Cathepsin L2
Protein CTSL2 PDB 1fh0.png
PDB rendering based on 1fh0.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CTSL2 ; CATL2; CTSU; CTSV
External IDs OMIM603308 MGI88564 HomoloGene76699 ChEMBL: 3272 GeneCards: CTSL2 Gene
EC number 3.4.22.43
RNA expression pattern
PBB GE CTSL2 210074 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1515 13039
Ensembl ENSG00000136943 ENSMUSG00000021477
UniProt O60911 P06797
RefSeq (mRNA) NM_001201575 NM_009984
RefSeq (protein) NP_001188504 NP_034114
Location (UCSC) Chr 9:
99.79 – 99.8 Mb
Chr 13:
64.36 – 64.37 Mb
PubMed search [1] [2]

Cathepsin L2, also known as cathepsin V and encoded by the CTSL2 gene, is a human gene.[1]

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes.

Clinical significance[edit]

Cathepsin L2 may play a role in the pathogenesis of keratoconus.[2]

References[edit]

  1. ^ "Entrez Gene: CTSL2 cathepsin L2". 
  2. ^ Kenney, M. C.; Chwa, M.; Atilano, S. R.; Tran, A.; Carballo, M.; Saghizadeh, M.; Vasiliou, V.; Adachi, W.; Brown, D. J. (2005) Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder. Invest. Ophthal. Vis. Sci. 46: 823-832. PMID 15728537

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C01.009

Further reading[edit]