Cathepsin W

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Cathepsin W
Identifiers
Symbols CTSW ; LYPN
External IDs OMIM602364 MGI1338045 HomoloGene37471 GeneCards: CTSW Gene
RNA expression pattern
PBB GE CTSW 214450 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1521 13041
Ensembl ENSG00000172543 ENSMUSG00000024910
UniProt P56202 P56203
RefSeq (mRNA) NM_001335 NM_009985
RefSeq (protein) NP_001326 NP_034115
Location (UCSC) Chr 11:
65.65 – 65.65 Mb
Chr 19:
5.47 – 5.47 Mb
PubMed search [1] [2]

Cathepsin W is a protein that in humans is encoded by the CTSW gene.[1][2][3]

The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.[3]

References[edit]

  1. ^ Linnevers C, Smeekens SP, Bromme D (May 1997). "Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes". FEBS Lett 405 (3): 253–9. doi:10.1016/S0014-5793(97)00118-X. PMID 9108299. 
  2. ^ Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D (Aug 1998). "Genomic structure, chromosomal localization, and expression of human cathepsin W". Biochem Biophys Res Commun 248 (2): 255–61. doi:10.1006/bbrc.1998.8954. PMID 9675123. 
  3. ^ a b "Entrez Gene: CTSW cathepsin W". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C01.037