Cbl TKB domain

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CBL proto-oncogene N-terminal domain 1 (four-helix bundle)
PDB 1b47 EBI.jpg
structure of the n-terminal domain of cbl in complex with its binding site in zap-70
Identifiers
Symbol Cbl_N
Pfam PF02262
InterPro IPR003153
SCOP 1b47
SUPERFAMILY 1b47
CBL proto-oncogene N-terminus, EF hand-like domain
PDB 1b47 EBI.jpg
structure of the n-terminal domain of cbl in complex with its binding site in zap-70
Identifiers
Symbol Cbl_N2
Pfam PF02761
InterPro IPR014741
SCOP 1b47
SUPERFAMILY 1b47
CBL proto-oncogene N-terminus, SH2-like domain
PDB 1b47 EBI.jpg
structure of the n-terminal domain of cbl in complex with its binding site in zap-70
Identifiers
Symbol Cbl_N3
Pfam PF02762
InterPro IPR014742
SCOP 1b47
SUPERFAMILY 1b47

In molecular biology, the Cbl TKB domain (tyrosine kinase binding domain), also known as the phosphotyrosine binding (PTB) domain is a conserved region found at the N-terminus of Cbl adaptor proteins. This N-terminal region is composed of three evolutionarily conserved domains: an N-terminal four-helix bundle domain, an EF hand-like domain and a SH2-like domain, which together are known to bind to phosphorylated tyrosine residues.


References[edit]

This article incorporates text from the public domain Pfam and InterPro IPR014742

This article incorporates text from the public domain Pfam and InterPro IPR014741

This article incorporates text from the public domain Pfam and InterPro IPR003153