Cefacetrile
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| Systematic (IUPAC) name | |
| (6R,7R)-3-(acetyloxymethyl)-7-[(2-cyanoacetyl)amino]- 8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylic acid |
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| Clinical data | |
| Trade names | Celospor, Celtol, Cristacef |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ℞ Prescription only |
| Routes | Intravenous, intramuscular, intramammary |
| Pharmacokinetic data | |
| Protein binding | 23 to 38% |
| Half-life | 1.2 hours |
| Excretion | Renal (72%) |
| Identifiers | |
| CAS number | 10206-21-0  |
| ATC code | J01DB10 QJ51DB10 |
| PubChem | CID 91562 |
| DrugBank | DB01414 |
| ChemSpider | 82675 |
| UNII | FDM21QQ344 |
| KEGG | D07629 |
| Chemical data | |
| Formula | C13H13N3O6S |
| Mol. mass | 339.325 g/mol |
| SMILES | eMolecules & PubChem |
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Cefacetrile (INN, also spelled cephacetrile) is a broad-spectrum first generation cephalosporin antibiotic effective in Gram-positive and Gram-negative bacterial infections. It is a bacteriostatic antibiotic.[1][2] Cefacetrile is marketed under the trade names Celospor, Celtol, and Cristacef,[3] and as Vetimast for the treatment of mammary infections in lactating cows.[2]
[edit] References
- ^ "Cefacetrile Summary Report". European Medicines Agency, Committee for Veterinary Medicinal Products. 1998. http://www.emea.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500011465.pdf.
- ^ a b Haberfeld, H, ed. (2007) (in German). Austria-Codex (2007/2008 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 3-85200-183-8.
- ^ Horiuchi, N.; Oyakawa, Y.; Oka, R.; Fujiwara, T. (1980). "Clinical evaluation of cephacetrile (Celtol) for respiratory infections (author's transl)". The Japanese journal of antibiotics 33 (10): 1145–1155. PMID 7206219.
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