|Systematic (IUPAC) name|
|Pregnancy cat.||B1 (AU)|
|Legal status||POM (UK) Discontinued (US)|
|Excretion||Mostly renal, as unchanged drug|
|Mol. mass||462.505 g/mol|
| (what is this?)
Cefamandole (INN, also known as cephamandole) is a second-generation broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally.
Cefamandole is no longer available in the United States.
Adverse effects 
The chemical structure of cefamandole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase)(vitamin K supplement is recommended during therapy) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.
CO2 is generated during the normal constitution of cefamandole & ceftazidim resulting in explosive like reaction in syringe
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