|Systematic (IUPAC) name|
|Trade names||Fixitol, Suprax,Fixbac by RAK Pharma, Triocim by Beximco Pharma Hebixime, Zenicef by Zenith Pharmaceuticals Ltd. Bangladesh., Posicef, Cefacef, CFX or Eficef|
|Legal status||℞ Prescription only|
|Bioavailability||40% to 50%|
|Protein binding||Approximately 60%|
Average 3 to 4 hours
|Excretion||Renal and biliary|
|Mol. mass||453.452 g/mol|
| (what is this?)
Cefixime (under the brand name of Suprax in the USA, Triocim by Beximco Pharma & under the brand name of Fixitol by Solmarc Lifesciences (P) Ltd ) is a cephalosporin antibiotic used to treat bacterial infections.
Spectrum of Bacterial Susceptibility and Resistance
Generally Haemolytic streptococci, Haemophilus parainfluenzee and moraxella catarrhalis are susceptible to Cefixime. While Listeria innocua, Pseudomonas aeruginosa and Staphylococcus aureus are resistant to Cefixime. Branhamella catarrhalis, Citrobacter freundii, Haemophilus influenzae and Moraxella catarrhalis have developed resistance towards Cefixime to varying degrees.For the detailed minimum inhibition concentration information, please refer to Cefixime Susceptibility and Resistance Data sheet.
Cefixime treats infections of the:
Ear: Otitis caused by Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes.
Throat: Tonsillitis, pharyngitis caused by Streptococcus pyogenes.
Chest and lungs: Bronchitis, pneumonia caused by Streptococcus pneumoniae and Haemophilus influenzae.
It is also use to treat Typhoid fever
Mechanism of action
The bactericidal action of cephalosporin due to the inhibition of cell wall synthesis. It binds to one of the penicillin binding proteins (PBPs) which inhibits the final transpeptidation step of the peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Only 40-50% is absorbed from the GI tract (oral). Rate may be decreased if taken with food. Absorption from oral suspensions than tablet.
It is always better to perform appropriate cultures and susceptibility studies to determine the causative organism and its sensitivity to Cefixime.
Cefixime is contraindicated in patients with known sensitivity or allergies to cephalosporin class of antibiotics. As Cefixime is a third generation cephalosporin, it is not contraindicated for patients with a true penicillin allergy. 
Adverse drug reactions include diarrhea, dyspepsia, nausea and vomiting. Hypersensitivity reactions like skin rashes, urticaria and Stevens-Johnson syndrome have been reported. There is no specific antidote for Cefixime overdosage. Gastric lavage may performed. Dialysis will not remove Cefixime in significant quantities.
The oral suspension form of Suprax 125 was re-launched by Lupin in the USA.The No.1 prescribed brand in India is ZIFI from FDC Ltd.
- "Cefixime Susceptibility and Resistance Data". Retrieved 22 July 2013.