|Systematic (IUPAC) name|
|Trade names||Suprax, Hebixime, Zenicef, Posicef, Cefacef or Eficef|
|Legal status||℞ Prescription only|
|Bioavailability||40% to 50%|
|Protein binding||Approximately 60%|
Average 3 to 4 hours
|Excretion||Renal and biliary|
|Mol. mass||453.452 g/mol|
| (what is this?)
Cefixime (under the brand name of Suprax in the USA, Zenicef by Zenith Pharmaceuticals Ltd. in Bangladesh, Posicef by Positive Medicare Pvt. Ltd. in India, Hebixime by atm Pharmaceuticals in Egypt and Eficef by Antibiotice Iaşi in Romania) is a cephalosporin antibiotic used to treat infections caused by bacteria.
Medical uses 
Cefixime treats infections of the:
Ear: Otitis caused by Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes.
Throat: Tonsillitis, pharyngitis caused by Streptococcus pyogenes.
Chest and lungs: Bronchitis, pneumonia caused by Streptococcus pneumoniae and Haemophilus influenzae.
Urinary system and genital organs: Uncomplicated gonorrhea caused by Neisseria gonorrhoeae.
Mechanism of action 
The bactericidal action of cephalosporin due to the inhibition of cell wall synthesis. It binds to one of the penicillin binding proteins (PBPs) which inhibits the final transpeptidation step of the peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Only 40-50% is absorbed from the GI tract (oral). Rate may be decreased if taken with food. Greater absorption from oral suspensions than tablet.
It is always better to perform appropriate cultures and susceptibility studies to determine the causative organism and its sensitivity to Cefixime.
Cefixime is contraindicated in patients with known sensitivity or allergies to cephalosporin class of antibiotics. As Cefixime is a third generation cephalosporin, it is not contraindicated for patients with a true penicillin allergy. 
Adverse effects 
Adverse drug reactions include diarrhea, dyspepsia, nausea and vomiting. Hypersensitivity reactions like skin rashes, urticaria and Stevens-Johnson syndrome have been reported. There is no specific antidote for Cefixime overdosage. Gastric lavage may performed. Dialysis will not remove Cefixime in significant quantities.
It was sold under the trade name Suprax in the USA until 2003 when it was taken off the market by drug manufacturer Wyeth after its patent expired. The oral suspension form of Suprax was re-launched by Lupin in the USA. In Bangladesh, it is sold as Roxim by Eskayef Bangladesh Limited. Suprax is still manufactured in Europe by Sanofi. 
Cefixime API is manufactured by many pharmaceutical companies all over the world. The major manufacturers are based in India.