|Systematic (IUPAC) name|
|Bioavailability||40% to 50%|
|Protein binding||Approximately 60%|
Average 3 to 4 hours
|Excretion||Renal and biliary|
|(what is this?)|
Cefixime is an antibiotic useful for the treatment of a number of bacterial infections. It is a third generation cephalosporin developed by Wyeth Pharmaceuticals. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Cefixime treats infections of the:
Ear: Otitis caused by Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes.
Throat: Tonsillitis, pharyngitis caused by Streptococcus pyogenes.
Chest and lungs: Bronchitis, pneumonia caused by Streptococcus pneumoniae and Haemophilus influenzae.
It is also used to treat typhoid fever
Spectrum of bacterial susceptibility
Cefixime is a broad spectrum cephalosporin antibiotic and is commonly used to treat bacterial infections of the ear, urinary tract, and upper respiratory tract. The following represents MIC susceptibility data for a few medically significant microorganisms:
- Escherichia coli: 0.015 µg/mL - 4 µg/mL
- Haemophilus influenzae: ≤0.004 µg/mL - >4 µg/mL
- Proteus mirabilis: ≤0.008 µg/mL - 0.06 µg/mL
Mechanism of action
The bactericidal action of Cefixime is due to the inhibition of cell wall synthesis. It binds to one of the penicillin binding proteins (PBPs) which inhibits the final transpeptidation step of the peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Only 40-50% is absorbed from the GI tract (oral). Rate may be decreased if taken with food. Absorption from oral suspensions than tablet is more.
It is always better to perform appropriate cultures and susceptibility studies to determine the causative organism and its sensitivity to cefixime.
Cefixime is contraindicated in patients with known sensitivity or allergies to cephalosporin class of antibiotics. As Cefixime is a third generation cephalosporin, it is not contraindicated for patients with a true penicillin allergy.
Adverse drug reactions include diarrhea, dyspepsia, nausea and vomiting. Hypersensitivity reactions like skin rashes, urticaria and Stevens-Johnson syndrome have been reported. There is no specific antidote for Cefixime overdosage. Gastric lavage may performed. Dialysis will not remove Cefixime in significant quantities.
- Alcohol - No major interaction has been observed between cefixime and alcohol.
Trade names include:
- Ofex (Delta Pharma Ltd. Bangladesh)
- Taxim-O (Alkem Laboratories Limited, India)
- C-3 (Astra Biopharmaceuticals Ltd. Bangladesh)
- "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.