|Systematic (IUPAC) name|
|Mol. mass||575.623 g/mol|
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Cefotetan is an injectable antibiotic of the cephamycin type for prophylaxis and treatment of bacterial infections. It is often grouped together with second-generation cephalosporins and has a similar antibacterial spectrum, but with additional anti-anaerobe coverage.
The chemical structure of cefotetan, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.
Spectrum of Bacterial Susceptibility and Resistance
Fusobacterium necrophorum, Peptoniphilus lacrimalis and Propionibacterium acnes are generally susceptible to Cefotetan. While Bacteroides fragilis, Bordetella bronchiseptica are resistant towards Cefotetan. Bacterials like Clostridium cadaveris, Porphyromonas and Weeksella virosa have developed resistance towards Cefotetan. For the detailed minimum inhibition concentration of Cefotetan, please refer to theFor the detailed minimum inhibition concentration information, please refer to Cefotetan Susceptibility and Resistance Data sheet.
- Stork CM (2006). "Antibiotics, antifungals, and antivirals". In Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA (eds.). Goldfrank's toxicologic emergencies. New York: McGraw-Hill. p. 847. ISBN 0-07-143763-0. Retrieved 2009-07-03.
- "Cefotetan Susceptibility and Resistance Data". Retrieved 23 July 2013.
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