Cefotetan
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| Systematic (IUPAC) name | |
| (7S)-7-{[4-(1-amino-3-hydroxy-1,3-dioxopropan-2-ylidene) 1,3-dithietane-2-carbonyl]amino}-7-methoxy- 3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo- 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
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| Clinical data | |
| AHFS/Drugs.com | Consumer Drug Information |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 69712-56-7  |
| ATC code | J01DC05 |
| PubChem | CID 53025 |
| DrugBank | DB01330 |
| ChemSpider | 47904 |
| UNII | 48SPP0PA9Q |
| KEGG | D00260  |
| ChEBI | CHEBI:3499 |
| ChEMBL | CHEMBL474579 |
| Chemical data | |
| Formula | C17H17N7O8S4 |
| Mol. mass | 575.623 g/mol |
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Cefotetan is an injectable antibiotic of the cephamycin type for prophylaxis and treatment of bacterial infections. It is often grouped together with second-generation cephalosporins and has a similar antibacterial spectrum, but with additional anti-anaerobe coverage.
Cefotetan was developed by Yamanouchi. It is marketed outside Japan by AstraZeneca with the brand names Apatef and Cefotan.
Adverse effects [edit]
The chemical structure of cefotetan, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.[1]
References [edit]
- ^ Stork CM (2006). "Antibiotics, antifungals, and antivirals". In Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA (eds.). Goldfrank's toxicologic emergencies. New York: McGraw-Hill. p. 847. ISBN 0-07-143763-0. Retrieved 2009-07-03.
External links [edit]
- Cefotan official web site run by AstraZeneca US
- Cefotetan entry in RxList
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