|Systematic (IUPAC) name|
|Trade names||Generic (formerly Vantin)|
|Pregnancy cat.||B1 (AU) B (US)|
|Legal status||℞-only (US)|
|Protein binding||21% to 29%|
|Metabolism||Negligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the liver|
|Mol. mass||427.458 g/mol|
|(what is this?)|
Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. Currently, it is only marketed as generic preparations in the USA, according the FDA Orange Book. It is commonly used to treat acute otitis media, pharyngitis, sinusitis, and gonorrhea. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.
Pfizer, the parent company of Pharmacia & Upjohn, markets cefpodoxime proxetil under the trade name C-Doxim (C-doxim 50Dt,drysyp,100Dt/drysyp,200 and Cv200by Neomed(India) Simplicef for veterinary use. The dose range in dogs is 5–10 mg/kg body weight, administered orally, once a day.
(Finecure, India) markets the products under trade name Cefpo (Cefpo 100Dt, 200, Cv and Dry Syrup) 
Cefpodoxime inhibits cell wall synthesis by inhibiting final transpeptidation step of peptidoglycan synthesis in cell walls. It has well established pharmacokinetic profile with absorption of 50%. It is indicated in Community Acquired Pneumonia, Uncomplicated Skin and Skin Structure Infections and Uncomplicated Urinary Tract Infections.
Spectrum of bacterial susceptibility and resistance
Cefpodoxime has been used to fight pathogenic bacteria responsible for causing gonorrhoeae, tonsillitis, pneumonia, and bronchitis. Representative pathogenic genera include Streptococcus, Haemophilus, and Neisseria. The following represents MIC susceptibility data for a few medically significant microorganisms.
- Haemophilus influenzae: ≤0.03 μg/ml - 1 μg/ml
- Neisseria gonorrhoeae: 0.004 μg/ml - 0.06 μg/ml
- Streptococcus pyogenes: ≤0.004 μg/ml - 2 μg/ml
- "Anti Biotics and Anti Bacterial". Finecurepharmaceuticalsltd. Retrieved 2012-03-27.
- PubChem 6526396 - cefpodoxime proxetil
- Vantin Tablets and Oral Suspension Torpod (Torrent)Full U.S. Prescribing Information (from manufacturer's website)
- Simplicef (from manufacturer's website)