Ceftiofur

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Ceftiofur
Ceftiofur.png
Systematic (IUPAC) name
(6R,7R)-7-[ [(2Z)-2-(2-Amino-1,3-thiazol-4-yl)- 2-methoxyiminoacetyl]amino]-3-(furan-2- carbonylsulfanylmethyl)-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Identifiers
CAS number 80370-57-6 YesY
ATCvet code QJ01DD90 QJ51DD90
PubChem CID 6328657
ChemSpider 4886668 YesY
UNII 83JL932I1C YesY
KEGG D07657 YesY
ChEMBL CHEMBL222913 YesY
Chemical data
Formula C19H17N5O7S3 
Mol. mass 523.56 g/mol
 YesY (what is this?)  (verify)

Ceftiofur is an antibiotic of the cephalosporin type (third generation), licensed for use in veterinary medicine. It was first described in 1987.[1] It is marketed by pharmaceutical company Pfizer as Excenel,[2] and is the active ingredient in that company's Specramast LC (lactating cow formula) product.

It is resistant to the antibiotic resistance enzyme beta-lactamase, and has activity against Gram-positive and Gram-negative bacteria. E. coli strains resistant to ceftiofur have been reported.[3]

References[edit]

  1. ^ Yancey RJ, Kinney ML, Roberts BJ, Goodenough KR, Hamel JC, Ford CW (1987). "Ceftiofur sodium, a broad-spectrum cephalosporin: evaluation in vitro and in vivo in mice". Am. J. Vet. Res. 48 (7): 1050–3. PMID 3631686. 
  2. ^ "Pfizer Animal Health Dairy Information on Products and Solutions". Retrieved 2007-11-20. 
  3. ^ Donaldson SC, Straley BA, Hegde NV, Sawant AA, DebRoy C, Jayarao BM (2006). "Molecular epidemiology of ceftiofur-resistant Escherichia coli isolates from dairy calves". Appl. Environ. Microbiol. 72 (6): 3940–8. doi:10.1128/AEM.02770-05. PMC 1489609. PMID 16751500. 

External links[edit]