Cell cortex

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The cell cortex is a specialized layer of cytoplasm on the inner face of the plasma membrane that functions as a mechanical support of the plasma membrane. In animal cells it is an actin-rich layer responsible for movements of the cell surface.[1][2] In plant cells, the cell cortex is reinforced by cortical microtubules underlying the plasma membrane. The direction of these cortical microtubules determines which way the cell elongates when it grows.

In some animal cells, the protein spectrin may be present in the cortex. Spectrin helps to create a network by cross-linking actin filaments.[2] The proportions of spectrin and actin vary in different cell types.[3] Spectrin proteins and actin microfilaments are attached to transmembrane proteins by attachment proteins between them and the transmembrane proteins. The cell cortex is attached to the inner (cytosolic) face of the plasma membrane in cells where the spectrin proteins and actin microfilaments form a mesh-like structure much like a fishnet except that it can be broken and reformed. This breakage and reformation is referred to as "dynamic instability."


  1. ^ Pesen D, Hoh JH (January 2005). "Micromechanical architecture of the endothelial cell cortex". Biophys. J. 88 (1): 670–9. doi:10.1529/biophysj.104.049965. PMC 1305044. PMID 15489304. 
  2. ^ a b Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter (2002). "Cross-linking Proteins with Distinct Properties Organize Different Assemblies of Actin Filaments". Molecular Biology of the Cell (4th ed.). New York: Garland Science. ISBN 0-8153-3218-1. 
  3. ^ Machnicka B, Grochowalska R, Bogusławska DM, Sikorski AF, Lecomte MC (January 2012). "Spectrin-based skeleton as an actor in cell signaling". Cell. Mol. Life Sci. 69 (2): 191–201. doi:10.1007/s00018-011-0804-5. PMC 3249148. PMID 21877118.