Centella asiatica, commonly known as centella and gotu kola, is a small, herbaceous, annual plant of the family Mackinlayaceae or subfamily Mackinlayoideae of family Apiaceae, and is native to wetlands in Asia. It is used as a medicinal herb in Ayurvedic medicine, traditional African medicine, and traditional Chinese medicine. It is also known as the Asiatic pennywort or Indian pennywort in English, among various other names in other languages.
Centella grows in tropical swampy areas. The stems are slender, creeping stolons, green to reddish-green in color, connecting plants to each other. It has long-stalked, green, rounded apices which have smooth texture with palmately netted veins. The leaves are borne on pericladial petioles, around 2 cm. The rootstock consists of rhizomes, growing vertically down. They are creamish in color and covered with root hairs.
The flowers are white or pinkish to red in color, born in small, rounded bunches (umbels) near the surface of the soil. Each flower is partly enclosed in two green bracts. The hermaphrodite flowers are minute in size (less than 3 mm), with 5-6 corolla lobes per flower. Each flower bears five stamens and two styles. The fruit are densely reticulate, distinguishing it from species of Hydrocotyle which have smooth, ribbed or warty fruit. The crop matures in three months, and the whole plant, including the roots, is harvested manually.
Centella grows along ditches and in low, wet areas. In Indian and Southeast Asian centella, the plant frequently suffers from high levels of bacterial contamination, possibly from having been harvested from sewage ditches. Because the plant is aquatic, it is especially sensitive to pollutants in the water, which are easily incorporated into the plant.
Centella is used as a leafy green in Sri Lankan cuisine, where it is called gotu kola. In Sinhalese, gotu is translated as "conical shape" and kola as "leaf". It is most often prepared as malluma (මැල්ලුම), a traditional accompaniment to rice and curry, and goes especially well with vegetarian dishes, such as dhal, and jackfruit or pumpkin curry. It is considered quite nutritious. In addition to finely chopped gotu kola, malluma almost always contains grated coconut, and may also contain finely chopped green chilis, chili powder, turmeric powder and lime (or lemon) juice. A variation of the nutritious porridge known as kola kenda is also made with gotu kola by the Sinhalese people of Sri Lanka. Kola Kenda is made with very well-boiled red rice (with extra liquid), coconut milk and gotu kola, which is pureed. The porridge is accompanied with jaggery for sweetness. Centella leaves are also used in sweet "pennywort" drinks.
In Vietnam and Thailand, this leaf is used for preparing a drink or can be eaten in raw form in salads or cold rolls. In Bangkok, vendors in the famous Chatuchak Weekend Market sell it alongside coconut, roselle, chrysanthemum, orange and other health drinks.
It is one of the constituents of the Indian summer drink thandaayyee.
In Bangladeshi cuisine mashed centella is eaten with rice and is popular for its medicinal properties.
Centella asiatica has large amounts of pentacyclic triterpenoids including asiaticoside, brahmoside, asiatic acid, and brahmic acid. Other products include centellose, centelloside, and madecassoside.
According to the American Cancer Society, although centella is promoted for its health benefits, "available scientific evidence does not support claims of its effectiveness for treating cancer or any other disease in humans". However some research has shown a possible health benefit in the form of reduction of the progression of subclinical arterial lesions in low-risk asymptomatic subjects.[non-primary source needed]
In South Asia, other common names of centella include సరస్వతి ఆకు (sarswathi aku) in Telugu; കുടവൻ (kudavan), മുത്തിൾ (muththil), or കുടങ്ങൽ (kudangal) in Malayalam; থানকুনি (thankuni) in Bengali; ගොටුකොල (gotu kola) in Sinhala; मधुकपर्णी (mandukaparni) in Sanskrit; ब्राम्ही / ब्राह्मी (brahmi) in Marathi: ಒಂದೆಲಗ (ondelaga) in Kannada; வல்லாரை (vallaarai) in Tamil; brahmi booti in Hindi; perook in Manipuri; মানিমুনি (manimuni) in Assamese; timare in Tulu; tangkuanteh in Paite; ब्रह्मबुटि (brahmabuti) or घोडताप्रे (ghod-tapre) in Nepali; and खोलचा घायँ (kholcha ghyan) in Newari (Nepal Bhasa).
In India, particularly, it is popularly known by a variety of names: bemgsag, brahma manduki, brahmanduki, brahmi, ondelaga or ekpanni (south India, west India), sarswathi aku (Andhra Pradesh), gotu kola, khulakhudi, mandukparni, mandookaparni, or thankuni (Bengal), depending on region. Bacopa monnieri is the more widely known Brahmi; both have some common therapeutic properties in Vedic texts and are used for improving memory. C. asiatica is called brahmi particularly in north India, although that may be a case of mistaken identity introduced during the 16th century, when brahmi was confused with mandukaparni, a name for C. asiatica.  Probably the earliest study of mandookaparni as medya rasayana (improving the mental ability) was carried out at the Dr. A. Lakshmipathy Research Centre (now under CCRAS).
In Southeast Asia, it is known as ស្លឹកត្រចៀកក្រាញ់ (sleuk tracheakkranh) in Khmer; မြင်းခွာပင် (mying khwar ) in Burmese; ใบบัวบก (bai bua bok) in Thai; rau má ("mother vegetable") in Vietnamese; pegagan or antanan in Indonesian; takip-kohol (literally "snail lid") or yahong yahong ("little bowl") in Filipino; and pegagan or pegaga in Malay.
Gotu kola is a minor feature in the longevity tradition of the T'ai chi ch'uan master Li Ching-Yuen. He purportedly lived to be 197 or 256, due in part to his usage of traditional Chinese herbs, including gotu kola.
- "Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all.". Indian J Pharm Sci: 546–56. September 2010.
- United States Department of Agriculture. "Plant Profile for Centella asiatica". Retrieved 15 July 2012 (Use Native Status Link on Page).
- Floridata. "Centella asiatica". Retrieved 15 July 2012.
- Meschino Health. "Comprehensive Guide to Gotu Kola (Centella asiatica)". Retrieved 15 July 2012.
- "Leaf Extract Treatment During the Growth Spurt Period Enhances Hippocampal CA3 Neuronal Dendritic Arborization in Rats". Evid Based Complement Alternat Med: 349–57. September 2006.
- "Nasi ulam". Retrieved 2009-05-07.
- Singh, B. and Rastogi, R.P. 1968. Chemical examination of Centalla Asiatica Linn - III. Constitution of brahmic acid. Phytochemistry 7: 1385-1393. Singh B. and Rastogi, R. P. 1969. A reinvestigation of the triterpenes of Centella Asiatica. Phytochemistry 8: 917-921.
- "Gotu Kola". American Cancer Society. 28 November 2011. Retrieved August 2013.
- "Pycnogenol® and Centella Asiatica for asymptomatic atherosclerosis progression". International Angiology. 33(1): 20–26. February 2014.
- Daniel, M. (2005). Medicinal plants: chemistry and properties. Science Publishers. p. 225. ISBN 978-1-57808-395-4.
- "In north India, however, brāhmī is commonly identified as Centella asiatica (Linn.) Urban, which in Malayalam is known as muttil. It seems that this identification of brāhmī as C. asiatica has been in use for long in northern India, as Hēmādri's 'Commentary on Aṣṭāṅgahṛdayaṃ (Āyuṛvēdarasāyanaṃ) treats maṇḍūkapaṛṇī (C. asiatica) as a synonym of brahmi." Warrier, P K; V P K Nambiar, C Ramankutty, V.P.K. & Ramankutty, R Vasudevan Nair (1996). Indian Medicinal Plants: A Compendium of 500 Species, Volume 1. Orient Blackswan. p. 238. ISBN 978-81-250-0301-4.
- Khare, C. P. (2003). Indian Herbal Remedies: Rational Western Therapy, Ayurvedic, and Other Traditional Usage, Botany. Springer. p. 89. ISBN 978-3-540-01026-5.
- "Mandukaparni (Centella asiatica)". National R & D Centre for Rasayana. Retrieved 15 August 2013.
- Appa Rao MVR, Srinivas K, Koteshwar Rao T. "The effect of Mandookaparni (Centella asiatica) on the general mental ability (medhya) of mentally retarded children". J. Res Indian Med. 1973;8:9–16.
- "Takip-kohol / Centella asiatica / Pennyworth: Philippine Medicinal Herbs / Philippine Alternative Medicine". Stuartxchange.org. Retrieved 2014-03-22.
- Caldecott, Todd (2006). Ayurveda: The Divine Science of Life. Elsevier/Mosby. ISBN 0-7234-3410-7. Contains a detailed monograph on Centella asiatica (Mandukaparni; Gotu Kola) as well as a discussion of health benefits and usage in clinical practice