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Central Colorado is a region of the U.S. state of Colorado. Central Colorado is home to most of the population of the state and its geography is dominated by the Rocky Mountains, their foothills, mesas, and canyons, the rivers that run through them, and the open plains off of the foothills. Central Colorado can be separated into two regions known as the north central region and the south central region. Central Colorado is home to the two largest cities in Colorado, Denver and Colorado Springs.