Cephalic flexure

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Cephalic flexure
Brain of human embryo of four and a half weeks, showing interior of fore-brain. (Cephalic flexure visible at center top.)
Latin flexura mesencephalica
Gray's p.737
Code TE E5.

The mesencephalic flexure or cephalic flexure is the first flexure, or bend, of the embryonic brain; it appears in the region of the mid-brain. In human embryos it generally occurs at the end of the 3rd week/beginning of 4th.

By means of it the fore-brain is bent in a ventral direction around the anterior end of the notochord and fore-gut, with the result that the floor of the fore-brain comes to lie almost antiparallel with that of the hind-brain.

This flexure causes the mid-brain to become, for a time, the most prominent part of the brain, since its dorsal surface corresponds with the convexity of the curve. As a consequence, the cardiac plate, which was previously anterior to the forebrain, approximates its adult location in what will become the thoracic region.

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This article incorporates text from a public domain edition of Gray's Anatomy.