|Type||Subsidiary of Teva Pharmaceutical Industries|
|Headquarters||Frazer, Pennsylvania, United States|
|Key people||J. Kevin Buchi, CEO|
|Employees||3,726 (as of December 31, 2010)|
Cephalon, Inc. is a U.S. biopharmaceutical company co-founded in 1987 by Dr. Frank Baldino, Jr., a pharmacologist and former scientist with the DuPont Company, who served as the company's chairman and chief executive officer until his death in December 2010. The company's name comes from the adjective "cephalic" meaning "related to the head or brain," and it was established primarily to pursue treatments for neurodegenerative diseases.
Sales revenues reached $2.8 billion in 2010, ranking Cephalon among the leading biopharmaceutical companies in the world. In 2006, industry publication MedAd News named the company one of the ten most respected biotechnology firms in the world. Cephalon employs more than 3,700.
Cephalon was first included in the Fortune 1000 list of U.S. companies based upon annual revenues for 2006.
The company's early research efforts were focused on the development of IGF-1, an insulin-like growth factor, under a collaboration with Chiron Corporation to treat amyotrophic lateral sclerosis, or Lou Gehrig's Disease, but the product has never been approved.
More recently, the company developed and commercialized products for the treatment of sleep disorders, pain, addiction and cancer, establishing the "wake franchise" on the basis of Provigil (Modafinil) and later Nuvigil, with the R-enantiomer of modafinil. In addition to conducting research on kinase inhibitors and other small molecules, it has licensed compounds and acquired both products and other companies, including CIMA Labs, Anesta, and Laboratoire Lafon. It was from the latter company that Cephalon obtained the rights to modafinil, which it marketed under the trade name Provigil for the treatment of excessive daytime sleepiness associated with narcolepsy, sleep apnea and shift work sleep disorder. Sales of Provigil reached nearly one billion dollars in 2008, by which time the company had acquired Lafon.
In February 2009, Cephalon announced its intention to acquire Australian biotechnology firm Arana Therapeutics, a move that represents one of the largest changes in the Australian life sciences landscape. The acquisition of Arana brings Cephalon its lead biologic candidate ART621 for inflammatory diseases. Moreover, Cephalon is acquiring biologics for the treatment of cancers. In February 2010, Cephalon exercised its option to acquire Ception Therapeutics, following receipt of positive data from a clinical study in adults with eosinophilic asthma. Commenting on this Frank Baldino, Jr, the CEO of Cephalon, said “The acquisition of Ception is consistent with our strategy to diversify into biologics and provides us with an important phase three asset for further development.” 
Cephalon's Drug Discovery group is remarkable in that it has failed to produce a single FDA approved drug in its lifetime, which is due in part to having focused on difficult therapeutic areas such as neurodegenerative disorders. However, recent efforts have been more promising in that they have met some apparent clinical success in oncology, and have advanced several compounds from the company's internal research pipeline. These compounds still require FDA approval however under new owners TEVA. In line with this progress in oncology the company agreed to acquire Australia's ChemGenex Pharmaceuticals, which provided Cephalon with marketing rights to Omapro, an experimental CML therapeutic agent.
The company has its corporate headquarters west of Philadelphia in Frazer, Pennsylvania and its research operations in nearby West Chester, as well as manufacturing and other operations in suburban Minneapolis, Minnesota and Salt Lake City, Utah; its European operations are based near Paris, France.
Longtime chief financial officer J. Kevin Buchi succeeded Baldino as CEO in 2011. Members of the board include venture capitalist William Egan, former COR Therapeutics CEO Vaughan Kailian, prominent healthcare economist Dr. Gail Wilensky, former SmithKline Beecham executive Dr. Martyn Greenacre, former Harvard physician and Glaxo USA head Dr. Charles Sanders and former Ambassador Kevin Moley.
Legal Issues 
Cephalon settled a lawsuit for $17 million in which it faced claims that Baldino and other company executives had overstated the potential for a drug aimed at treating amyotrophic lateral sclerosis (known informally as Lou Gehrig's disease). The Federal Trade Commission claimed that Cephalon had made improper deals to postpone the availability of generic versions of modafinil. In September 2008, Cephalon paid $425 million to the federal government to settle four whistleblower lawsuits and a criminal charge alleging Cephalon had marketed Actiq, Gabitril and Provigil for “off-label” (unapproved) uses.
Select products that Cephalon manufactures and markets include:
- Actiq (fentanyl citrate) - Cancer pain
- Amrix (cyclobenzaprine) - Muscle relaxant
- Fentora (fentanyl) - Cancer pain
- Gabitril (tiagabine) - Seizures
- Nuvigil (armodafinil) - Narcolepsy
- Provigil (modafinil) - Narcolepsy
- Treanda (bendamustine) - Indolent B-cell non-Hodgkin's lymphoma (NHL) and Chronic lymphocytic leukemia
- Trisenox (arsenic trioxide) - Acute promyelocytic leukemia treatment
Pipeline Candidates 
Select candidates in Cephalon's pipeline include:
- CEP-26401 - Alzheimer's Disease
- CEP-701 (Lestaurtinib) - Malignancies
- Lupuzor - Systemic lupus erythematosus (Phase IIB trial complete  )
- CEP-18770 - multiple myeloma
- Meier, Barry. "Frank Baldino Jr., Founder of Pharmaceutical Company, Dies at 57", The New York Times, December 21, 2010. Retrieved December 24, 2010.
- Cephalon To Acquire Ception Therapeutics. Archived 1 February 2011 at WebCite
- Bennett, Simeon (29 March 2011), "Cephalon agrees to acquire ChemGenex: Potential leukemia drug key to $230M purchase", Delaware Online (Bloomburg News), retrieved 30 March 2011
- "Cephalon, Inc. - Company Profile, Information, Business Description, History, Background Information on Cephalon, Inc.". Referenceforbusiness.com. Retrieved 2012-04-18.
- "Cephalon pays $425 million to settle unique off-label marketing case brought by whistleblower", Phillips and Cohen LLP Press Release, September 29, 2008.
- ImmuPharma announces Positive Ph2b Lupuzor trial results - Drugs.com MedNews Archived 1 February 2011 at WebCite
- "Oncology pipeline Oct 2009". Archived from the original on 2011-02-01.