||This article appears to be written like an advertisement. (December 2007)|
Ceragenix Pharmaceuticals, Inc. (OTC Pink: CGXP) is a biopharmaceutical company headquartered in Denver, Colorado that develops prescription therapies based on a platform of proprietary surface active technologies—skin Barrier Repair Technology (BRT) and Cerageninis, a new class of broad spectrum anti-infectives. The company that discovers, develops and commercializes anti-infective drugs based on its proprietary class of compounds, Ceragenins. Active against a broad range of gram positive and gram negative bacteria, these agents are being developed as anti-infective medical device coatings and as therapeutics for serious antibiotic-resistant organisms.
Research and development
Ceragenix's second platform technology addresses the growing threat of multidrug resistant bacterial and viral infections. The Ceragenin anti-infective technology is based on the research of Dr. Paul B. Savage, Professor and Associate Chair of Departments of Chemistry and Biochemistry at Brigham Young University (BYU, Provo, Utah). These compounds are aminosterols that mimic the activity of the naturally occurring antimicrobial peptides which form part of the human body's innate immune system and early line of defense against bacterial, viruses, fungi and even certain cancers. The Ceragenins have been the subject of extensive in vitro analysis and have demonstrated a broad range of action against clinically relevant organisms such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Staphylococcus aureus (VRSA), tobramycin-resistant Pseudomonas aeruginosa (PATR), Escherichia coli, vaccinia virus, HIV, and Bacillus anthracis (anthrax) among others. The compounds work by tearing apart the outer membranes of their targets. The compounds are positively charged and are electrostatically attracted to the negatively-charged phospholipids that tend to distinguish prokaryotic from eukaryotic cells. Ceragenix is currently working on developing a wound dressing for medical device insertion points to help reduce the incidence of hospital acquired infections which claim over 50,000 lives each year in the United States.
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