|West end||IL 56 (Butterfield Rd.) in Oak Brook|
|East end||Martin Luther King Drive|
Cermak Road, also known as "Twenty-Second Street", is a 19-mile-long, major east-west artery on Chicago's near south and west sides and the city's western suburbs. In Chicago's street numbering system, Cermak is 2200 south, or twenty-two blocks south of the baseline, Madison Avenue. Normally, one mile comprises eight Chicago blocks, but the arterial streets Roosevelt Road, formerly named Twelfth Street and at 1200 South, and Cermak Road (Twenty-Second Street) were platted before the eight-blocks-per-mile plan was implemented. Roosevelt Road is one mile south of Madison Avenue and there are twelve blocks within that mile. Cermak Road is two miles south of Madison Avenue and there are ten blocks within the mile between Roosevelt and Cermak Roads.
The street was named after Democratic politician Anton Cermak, Mayor of Chicago from 1931 until 1933. Cermak was shot and killed on February 15, 1933, by an assassin who was aiming for President Franklin Roosevelt. Cermak was a Czech immigrant credited with creating a multi-ethnic Democratic political coalition that included formerly Republican African Americans. The street was chosen to honor Cermak because it passes through the neighborhoods of Pilsen and Lawndale, both at the time heavily Czech-American. The adjoining suburbs of Cicero and Berwyn were also home to a large Czech population during the first half of the 20th century.
Points of interest
A trip from east to west along Cermak Road traces a historical timeline of the Chicago area, from Yankee industrialists' masonry mansions in the Prairie District on the lakeshore, to mammoth printing presses and manufactories banking the Chicago River and Sanitary Canal, past immigrants' crowded brick housing, schools and churches, along boulevards of temporary middle class success and massive plants that produced twentieth century equipment for the nation, through commercial districts made up of shops and savings banks that boomed in the Roaring Twenties. Further west, a river and forests curtained off the farmland that was eventually developed into asphalt-encircled shopping malls or steel-framed, glass-walled corporate towers. Transportation evolved from waterborn lake and river vessels to steam powered railroads reaching across the continent and electrified urban systems connecting neighborhoods and towns to super highways overlaying all of the predecessors.
Cermak Road's practical eastern end is Martin Luther King Drive at McCormick Place, a huge exposition center that straddles Lake Shore Drive, in the Near South Side, Chicago community area. King Drive curves west and feeds into Cermak with a lane continuing north into one-way Calumet Avenue.
The building, the former headquarters of R.R. Donnelly, is an official landmark. On the northwest corner of Calumet Avenue is another landmark, the American Book Company Building built in 1912 at 320-330 E. Cermak.
At the southeast corner of Michigan Avenue once sat Prohibition-era mobster Al Capone's headquarters from 1928 until 1932, the Lexington Hotel, which was built in 1892, vacated in 1980, and demolished in 1995.
Michigan Avenue to the north and south is designated the Motor Row Landmark Area, which commemorates the earliest days of automobile retail showrooms. At the southeast corner of Wabash Avenue is a restored 1930's fast-food pioneer, White Castle #16. The official landmark is located diagonally opposite to a modern working White Castle. The Chicago Transit Authority Green Line, the "alley el"  runs above the alley between Wabash and State, with Roosevelt Road and 35th Street being the nearest stations since the Cermak stop was removed in 1978. In 2011, plans were announced to build a new $50 million Cermak Station.
Hilliard Homes, public housing units designed in the mid 1960s by Bertrand Goldberg, are at State Street. On the opposite side, from State to Federal Streets, the Chicago Housing Authoriy's Harold Ickes Homes' eleven structures provided subsidized housing from 1955 until 2010. The National Teachers Elementary Academy, a public school at 55 W. Cermak, was subsequently built on the site.
Cermak Road now cuts through the north end of the community area Armour Square, heads west under Metra and CTA's Red Line, meets four exit lanes and two entrance lanes of the Dan Ryan and Adlai Stevenson Expressway Expressways, and then intersects with Chinatown's  main commercial strip, Wentworth Avenue. The historic On Leong Merchants Association Building and the ornamental Chinatown Gate are at the southwest corner. At 212 W. Cermak is a fire station, home of ALS Engine 8, BLS Truck 4, BLS Ambulance 85, and Battalion Chief 2.
Archer Courts Apartments, 2242 S. Princeton, is a 147 unit subsidized rental building built in 1951 by the CHA and placed into a TIF  in the late 1990s. The affordable rent apartment building was rehabilitated and is still owned by a non-profit entity, the Chicago Community Development Corporation.  Cermak Road, a newer axis of Chinatown, obliquely crosses the west-southwest angular artery Archer Avenue, dips to pass through a long chute underneath a viaduct beneath the Midway Airport Orange Line  and another rail line just east of Canal Street, and enters into a Chicago landmark area designated the Cermak Bridge District,  part of the Lower West Side.
Industrial Zone - Pilsen
The road traverses a Scherzer rolling lift type bridge  over the south branch of the Chicago River, past old factories, a cement plant  and the Carpenter Training Center, and then under the Dan Ryan Expressway(Interstates 90 and 94) to Halsted Street into the Pilsen  neighborhood, named for a city in the present-day Czech Republic..
A quarter-mile west of Halsted Street (800 West) is the historic Fisk Generating Station from Carpenter to Loomis, and from Cermak south to the Chicago river. At the southwest corner of Throop Street (1300W) stands a red brick structure topped with a radio antennae-equipped gothic tower that formerly housed Commonwealth Edison garages and warehouses, then Warshawsky & Sons JC Whitney automoblie parts supplier, and most recently subdivided warehouse spaces and indoor futbol (soccer) fields.  On the other side of the street, at May Street, is Dvorak Park.  Cermak is an industrial corridor up to the Benito Juarez Community Academy where southwest-northeast Blue Island Avenue diagonally crosses Ashland Avenue(1600 West)and Cermak Road. That stretch was of the street was upgraded using environmentally sustainable methods and materials in 2011 . The Loomis Avenue (1400W) bridge connects Pilsen to Bridgeport. The Chicago Transit Authority's elevated Pink Line  turns west at Paulina Avenue (1700 West),and runs parallel two blocks north of Cermak for approximately five miles to the town of Cicero.
Heart of the City
West of Ashland Avenue (1600 West), Cermak narrows to a lane in each direction. Parking lanes, sidewalks, and multi-unit storefront buildings abutting the sidewalks border the street. This commercial district contains restaurants, laundries, taverns, banks, clothing, and groceries. On the east side of Wolcott is the Cristo Rey Jesuit High School  which took over the site from St. Stephen's Church, a Slovene parish founded in 1898 . Southward on Hoyne (2100 West) is where the twin steeples of St. Paul Roman Catholic Church rise up from the church founded on 22nd Place by German immigrants in 1876. This area is known as the Heart of Chicago. At the northwest corner of Oakley is the public Josiah Pickard Elementary School , named for the Superintendent of Chicago Schools from 1864 to 1877.
Little Village - La Villita
West of Chicago's longest street, Western Avenue (2400 West), is the Little Village neighborhhood. The railroad at 2500 West marks the eastern border of community area South Lawndale . Commercial storefronts with apartments above continue to line both sides of the busy street. On the corner of Whipple (3030 West) is Our Lady of Tepeyac Catholic Church  which was built in 1919 as St. Casimir Catholic Church, a Polish immigrant parish. At the corner of Cermak Road and Marshall Boulevard is the famous Apollo 2000 Theater. Commonwealth Edison Troy Street Substation sits along the alley to the north and its namesake street.
Cermak Road doglegs to the north as it passes under a railroad viaduct near Trumbull. The Metra Burlington Northern rail line serves as the north boundary of the Little Village neighborhood as it heads southwest  to its terminus in Aurora, Illinois. West of the rail line and up to Ogden Avenue, the border between North and South Lawndale is Cermak Road. The street widens in North Lawndale and is banked by more residential structures, mainly brick two and three flats and corner storefronts in multi-unit buildings. Nearly two blocks south at 2348 S. Millard Avenue is Anton Cermak's home at the time of his death, registered as a historic place in 2011. After crossing Ogden Avenue and Pulaski Road and entering the neighborhood nicknamed K-Town, the westbound and eastbound lanes are divided by a grassy parkway median, causing Cermak to resemble a boulevard before meeting Chicago's western city limits at the Belt Railway  viaduct at 4600 West. The CTA Pink Line, having descended from an elevated position over Keeler Avenue to street level at Kildare Avenue, then makes a pair of southward offset bends between Kostner and Kilbourn Avenues, placing the tracks only a half block north of Cermak. The Pink Line, formerly the Douglas Park  leg of the O'Hare Line, heads straight west from there to its last stop, the Pink Line stationat 54th Avenue in Cicero, Illinois.
Town of Cicero
From the railroad to the southeast corner of Cermak and Cicero Avenue (Illinois Route 50) was the site, from 1905 until 1983 , of the Western Electric Company's famous Hawthorne Works,  which at one time employed 45,000 workers. Notorious criminal Al Capone's 1924 Cicero headquarters were located at the Hawthorne Inn, 4833 W. 22nd Street . Cermak Road expands west of Cicero Avenue and provides parking lanes on either side as it passes the three miles through the towns of Cicero and Berwyn, to Harlem Avenue and then on to suburbs to the west. At the northwest corner with Laramie Avenue (5200W) is a Commonwealth Edison Substation building and yard which also houses Chicago Transit Authority electrical equipment. The Olympic Theater, built in 1927, still stands at 6134 W. Cermak Rd .
City of Berwyn
Lombard Avenue (6200 West) is the western boundary. Nothing differentiates the two municipalities; no signs or landmarks announce the invisible border, and the street layout and building styles do not change. The U.S. Postal Service  has a large facility at 6625 West Cermak in the 60402 zip code. At Wesley (6700 West), Riverside Drive angles off to the southwest towards the eponymous suburb  designed by Frederick Law Olmsted. The road's width decreases here, at the western end of the grass and tree lined median and diagonal parking spaces, to two traffic lanes, a parallel parking lane, wide sidewalk and abutting storefront buildings on either side. At the southwest corner of Oak Park Avenue (6800 West) is the restored yet still vacant American State Bank building, built in 1925 . At the southeast corner of Harlem Avenue (Illinois Route 43), is the Cermak Plaza, an early shopping center which opened in 1956 . The noted Spindle sculpture, a tall spike impaling eight cars, decorated the parking lot until its May 2, 2008 dismantlement.
West of Harlem Avenue, Cermak Road is the boundary between Forest Park, IL to the north and North Riverside, IL to the south, location of the North Riverside Park Mall . Woodlawn Memorial Park , one of Forest Park's many cemeteries,  occupies the road's northern edge up to Des Plaines Avenue. The Showmen's League of America  maintains a final resting place for deceased outdoor show workers called the Showman's Rest  . A connected crematorium, columbarium and mausoleum occupy a narrow strip on the west side of Des Plaines Avenue. Just west of the mortuary, Forest Preserve District of Cook County (FPDCC)  picnic groves lie on both sides of the road. The Des Plaines River flows southward beneath a concrete bridge. The First Avenue cutoff allows westerly traffic to avoid the Chicago Central & Pacific R.R. diagonal grade crossing and turn right to head north on First Avenue Route 171. FPDCC Miller Meadow lies north of the cutoff and extends one mile to Roosevelt Road. Checkerboard Airfield , a U.S Air Mail facility, was located here from 1919 to 1927. Hobbyists can now fly radio controlled models from a designated landing field. The Riverside Golf Club , established in 1893, straddles the river and occupies the southeast corner of Cermak and First.