|Systematic (IUPAC) name|
|Mol. mass||1352.40 g/mol|
|(what is this?)|
Ceruletide (INN), also known as cerulein or caerulein, is a ten amino acid oligopeptide that stimulates smooth muscle and increases digestive secretions. Ceruletide is similar in action and composition to cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction. It is used to induce pancreatitis in experimental animal models.
Ceruletide was discovered and its structure elucidated in 1967 by Australian and Italian scientists from dried skins of the Australian green tree frog (Litoria caerulea, formerly Hyla caerulea). Its amino acid sequence is Pglu-Gln-Asp-Tyr[SO3H]-Thr-Gly-Trp-Met-Asp-Phe-NH2.
Induction of pancreatitis
Ceruletide upregulates pancreatic acinar cell intercellular adhesion molecule-1 (ICAM-1) proteins through intracellular upregulation of NF-κB. Surface ICAM-1 in turn promotes neutrophil adhesion onto acinar cells enhancing pancreatic inflammation. In addition to promoting the inflammatory cell reaction to acinar cells, ceruletide induces pancreatitis through dysregulation of digestive enzyme production and cytoplasmic vacuolization, leading to acinar cell death and pancreatic edema. Ceruletide also activates NADPH oxidase, a source of reactive oxygen species contributing to inflammation, as well as the Janus kinase/signal transducer, another inflammation inducer.
- A. Anastasi, V. Erspamer, and R. Endean (1967). "Isolation and structure of caerulein, an active decapeptide from the skin ofHyla caerulea". Experentia 23 (9): 699–700. doi:10.1007/BF02154119.
- G. De Caro, R. Endean, V. Esparmer, and M. Roseghini (1968). "Occurrence of caerulein in extracts of the skin of Hyla caerulea and other Australian hylids". Br J of Pharmac Chemother 33 (1): 48–58. PMC 1570274. PMID 5660165.
- V. Zaninovic, A. S. Gukovskaya, I. Gukovsky, M. Mouria and S. J. Pandol (2000). "Cerulein upregulates ICAM-1 in pancreatic acinar cells, which mediates neutrophil adhesion to these cells". Am J Physiol Gastrointest Liver Physiol 279 (4): G666–676. PMID 11005752.
- H. Kim (2008). "Cerulein Pancreatitis: Oxidative Stress, Inflammation, and Apoptosis". Gut and liver 167 (2): 74–80. doi:10.5009/gnl.2008.2.2.74. PMC 2871591. PMID 20485614.