After his father Dik Browne died in 1989, Browne took over drawing the family comic stripHi and Lois. The comic is syndicated throughout the United States and stars the characters Hi, Lois, Dot, Ditto, Chip, and Trixie. Hi and Lois is a part of King Features, as is the other Browne family comic strip Hägar the Horrible (done by Chance's brother Chris).
Chance Browne also plays guitar and sings in his band The Twinkies, a group that was formed in 1973. He has attended both Park College in Missouri and the School of Visual Arts in New York City. While he makes a living as a cartoonist, he has a true passion for painting, which he does in his spare time. Browne lives in Connecticut with his wife and three daughters.