Chelerythrine

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Chelerythrine
Skeletal formula of chelerythrine
Ball-and-stick model of the chelerythrine molecule
Names
IUPAC name
1,​2-​dimethoxy-​12-​methyl​[1,​3]benzodioxolo​[5,​6-​c]phenanthridin-​12-​ium
Identifiers
34316-15-9 N
ChEBI CHEBI:78373 N
ChEMBL ChEMBL258893 N
ChemSpider 2602 YesY
Jmol-3D images Image
PubChem 2703
UNII E3B045W6X0 YesY
Properties
C21H18NO4
Molar mass 348.37 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Chelerythrine is a benzophenanthridine alkaloid present in the plant Chelidonium majus (greater celandine). It is a potent, selective, and cell-permeable protein kinase C inhibitor.[1] It is also found in the plants Zanthoxylum clava-herculis and Zanthoxylum rhoifolium, exhibiting antibacterial activity against Staphylococcus aureus and other human pathogens.[2][3]

References[edit]

  1. ^ Chelerythrine from Fermentek
  2. ^ Gibbons, Simon; Leimkugel, Julia; Oluwatuyi, Moyo et al. (2003). "<Activity of Zanthoxylum clava‐herculis extracts against multi‐drug resistant methicillin‐resistant Staphylococcus aureus (mdr‐MRSA)>". Phytotherapy Research 17 (3): 274–275. doi:10.1002/ptr.1112. PMID 12672160. 
  3. ^ Tavares, Luciana de C; Zanon, Graciane; Weber, Andréia D. et al. (2014). "<Structure-activity relationship of benzophenanthridine alkaloids from Zanthoxylum rhoifolium having antimicrobial activity>". PLoS One 9 (5): e97000. doi:10.1371/journal.pone.0097000. PMID 24824737.