Chest pain may be a symptom of a number of serious conditions and is generally considered a medical emergency. Even though it may be determined that the pain is non-cardiac in origin, this is often a diagnosis of exclusion made after ruling out more serious causes of the pain.
Differential diagnosis 
- Acute coronary syndrome
- Aortic dissection
- Pericarditis and cardiac tamponade
- Arrhythmia - atrial fibrillation and a number of other arrhythmias can cause chest pain.
- Stable angina pectoris - this can be treated medically and although it warrants investigation, it is not an emergency in its strictest sense
- Mitral valve prolapse syndrome
- Aortic aneurysm
- Pulmonary embolism
- Pneumothorax and Tension pneumothorax
- Pleurisy - an inflammation which can cause painful respiration
- Lung malignancy
- Gastroesophageal reflux disease (GERD) and other causes of heartburn
- Hiatus hernia
- Achalasia, nutcracker esophagus and other neuromuscular disorders of the esophagus
- Functional dyspepsia
Chest wall 
- Costochondritis or Tietze's syndrome - a benign and harmless form of osteochondritis often mistaken for heart disease
- Spinal nerve problem
- Chest wall problems
- Precordial catch syndrome - another benign and harmless form of a sharp, localised chest pain often mistaken for heart disease
- Breast conditions
- Herpes zoster commonly known as shingles
- Bornholm disease
- Hyperventilation syndrome often presents with chest pain and a tingling sensation of the fingertips and around the mouth
- Da costa's syndrome
- Carbon monoxide poisoning
- Lead poisoning
- High abdominal pain may also mimic chest pain
- Prolapsed intervertebral disc
- Thoracic outlet syndrome
Diagnostic approach 
Knowing a patient's risk factors can be extremely useful in ruling in or ruling out serious causes of chest pain. For example, heart attack and thoracic aortic dissection are very rare in healthy individuals under 30 years of age, but significantly more common in individuals with significant risk factors, such as older age, smoking, hypertension, diabetes, history of coronary artery disease or stroke, positive family history (premature atherosclerosis, cholesterol disorders, heart attack at early age), and other risk factors.
In the emergency department the typical approach to chest pain involves ruling out the most dangerous causes: heart attack, pulmonary embolism, thoracic aortic dissection, esophageal rupture, tension pneumothorax and cardiac tamponade. By elimination or confirmation of the most serious causes, a diagnosis of the origin of the pain may be made. Often, no definite cause will be found and reassurance is then provided.
If acute coronary syndrome ("unstable angina") is suspected, many people are admitted briefly for observation, sequential ECGs, and determination of cardiac enzymes over time. On occasion, further tests on follow up may determine the cause. TIMI score performed at time of admission may help stratify risk. Features of the pain suggestive of cardiac ischaemia are describing the pain as heaviness; radiation of the pain to the neck, jaw or left arm; sweating; nausea; palpitations; the pain being felt upon exertion; dizziness; shortness of breath; and a "sense of impending doom."
Careful medical history and physical examination is essential in separating dangerous from trivial causes of disease, and the management of chest pain may be done on specialised units (termed medical assessment units) to concentrate the investigations. Occasionally, invisible medical signs will direct the diagnosis towards particular causes, such as Levine's sign in cardiac ischemia. A rapid diagnosis can be life-saving and often has to be made without the help of medical tests, however, additional tests are generally required to establish the diagnosis.
On the basis of the above, a number of tests may be ordered:
- X-rays of the chest and abdomen . Routine X-rays however are not needed.
- CT scanning may be used in unexplained chest pain when other tests are inconclusive.
- An electrocardiogram (ECG)
- V/Q scintigraphy or CT pulmonary angiogram(when a pulmonary embolism is suspected)
- Blood tests:
In people with chest pain supplemental oxygen is not needed unless the oxygen saturations are less than 94% or there are signs of respiratory distress. Entonox is frequently used by EMS personnel in the prehospital environment. There is however little evidence about its effectiveness.
Chest pain is the presenting symptom in about 12% of emergency department visits in the United States and has a one year mortality of about 5%.
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