Chickenpox

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For other uses, see Chickenpox (disambiguation).
"Varicella" redirects here. For other uses, see Varicella (disambiguation).
Not to be confused with Fowlpox or Smallpox.
Chickenpox
Varicela Aranzales.jpg
Male with varicella disease
Classification and external resources
Specialty Infectious disease
ICD-10 B01
ICD-9 052
DiseasesDB 29118
MedlinePlus 001592
eMedicine ped/2385 derm/74, emerg/367
Patient UK Chickenpox
MeSH C02.256.466.175

Chickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with varicella zoster virus (VZV).[1] The disease results in a characteristic skin rash that forms small, itchy blisters, which eventually scab over.[2] It usually starts on the face, chest, and back and then spreads to the rest of the body.[2] Other symptoms may include fever, feeling tired, and headaches.[2] Symptoms usually last five to ten days.[2] Complications may occasionally include pneumonia, inflammation of the brain, or bacterial infections of the skin among others.[3] The disease is often more severe in adults than children.[4] Symptoms begin ten to twenty one days after exposure to the virus.[5]

Chickenpox is an airborne disease which spreads easily through the coughs and sneezes of an infected person.[5] It may be spread from one to two days before the rash appears until all lesions have crusted over.[5] It may also spread through contact with the blisters.[5] Those with shingles may spread chickenpox to those who are not immune through contact with the blisters.[5] The disease can usually be diagnosed based on the presenting symptom;[6] however, in unusual cases may be confirmed by polymerase chain reaction (PCR) testing of the blister fluid or scabs.[4] Testing for antibodies may be done to determine if a person is or is not immune.[4] People usually only get the disease once.[5]

The varicella vaccine has resulted in a decrease in the number of cases and complications from the disease.[7] It protects about 70 to 90 percent of people from disease with a greater benefit for severe disease.[4] Routine immunization of children is recommended in many countries.[8] Immunization within three days of exposure may improve outcomes in children.[9] Treatment of those infected may include calamine lotion to help with itching, keeping the fingernails short to decrease injury from scratching, and the use of paracetamol (acetaminophen) to help with fevers.[5] For those at increased risk of complications antiviral medication such as aciclovir are recommended.[5]

Chickenpox occurs in all parts of the world.[4] Before routine immunization the number of cases occurring each year was similar to the number of people born.[4] Since immunization the number of infections in the United States has decreased nearly 90%.[4] In 2013 chickenpox resulted in 7,000 deaths globally – down from 8,900 in 1990.[10] Death occurs in about 1 per 60,000 cases.[4] Chickenpox was not separated from smallpox until the late 19th century.[4] In 1888 its connection to shingles was determined.[4] The first documented use of the term chicken pox was in 1684.[11] Why this term was used is not clear but it may be due to it being a relatively mild disease.[11]

Signs and symptoms[edit]

A single blister, typical during the early stages of the rash

The early (prodromal) symptoms in adolescents and adults are nausea, loss of appetite, aching muscles, and headache. This is followed by the characteristic rash or oral sores, malaise, and a low-grade fever that signal the presence of the disease. Oral manifestations of the disease (enanthem) not uncommonly may precede the external rash (exanthem). In children the illness is not usually preceded by prodromal symptoms, and the first sign is the rash or the spots in the oral cavity. The rash begins as small red dots on the face, scalp, torso, upper arms and legs; progressing over 10–12 hours to small bumps, blisters and pustules; followed by umbilication and the formation of scabs.[12][13]

At the blister stage, intense itching is usually present. Blisters may also occur on the palms, soles, and genital area. Commonly, visible evidence of the disease develops in the oral cavity and tonsil areas in the form of small ulcers which can be painful or itchy or both; this enanthem (internal rash) can precede the exanthem (external rash) by 1 to 3 days or can be concurrent. These symptoms of chickenpox appear 10 to 21 days after exposure to a contagious person. Adults may have a more widespread rash and longer fever, and they are more likely to experience complications, such as varicella pneumonia.[12]

Because watery nasal discharge containing live virus usually precedes both exanthem (external rash) and enanthem (oral ulcers) by 1 to 2 days, the infected person actually becomes contagious one to two days before recognition of the disease. Contagiousness persists until all vesicular lesions have become dry crusts (scabs), which usually entails four or five days, by which time nasal shedding of live virus ceases.

The condition usually resolves by itself within a couple of weeks.[14] The rash may, however, last for up to one month, although the infectious stage does not last longer than a week or two.[15]

Chickenpox is rarely fatal, although it is generally more severe in adult men than in women or children. Non-immune pregnant women and those with a suppressed immune system are at highest risk of serious complications. Arterial ischemic stroke (AIS) associated with chickenpox in the previous year accounts for nearly one third of childhood AIS.[16] The most common late complication of chickenpox is shingles (herpes zoster), caused by reactivation of the varicella zoster virus decades after the initial, often childhood, chickenpox infection.

Pregnancy and neonates[edit]

During pregnancy the dangers to the fetus associated with a primary VZV infection are greater in the first six months. In the third trimester, the mother is more likely to have severe symptoms.[17] For pregnant women, antibodies produced as a result of immunization or previous infection are transferred via the placenta to the fetus.[18] Women who are immune to chickenpox cannot become infected and do not need to be concerned about it for themselves or their infant during pregnancy.[19]

Varicella infection in pregnant women could lead to spread via the placenta and infection of the fetus. If infection occurs during the first 28 weeks of gestation, this can lead to fetal varicella syndrome (also known as congenital varicella syndrome).[20] Effects on the fetus can range in severity from underdeveloped toes and fingers to severe anal and bladder malformation. Possible problems include:

Infection late in gestation or immediately following birth is referred to as "neonatal varicella".[23] Maternal infection is associated with premature delivery. The risk of the baby developing the disease is greatest following exposure to infection in the period 7 days before delivery and up to 8 days following the birth. The baby may also be exposed to the virus via infectious siblings or other contacts, but this is of less concern if the mother is immune. Newborns who develop symptoms are at a high risk of pneumonia and other serious complications of the disease.[24]

Diagnosis[edit]

The diagnosis of chickenpox is primarily based on the signs and symptom, with typical early symptoms followed by a characteristic rash. Confirmation of the diagnosis is by examination of the fluid within the vesicles of the rash, or by testing blood for evidence of an acute immunologic response.

Vesicular fluid can be examined with a Tzanck smear, or better by testing for direct fluorescent antibody. The fluid can also be "cultured", whereby attempts are made to grow the virus from a fluid sample. Blood tests can be used to identify a response to acute infection (IgM) or previous infection and subsequent immunity (IgG).[25]

Prenatal diagnosis of fetal varicella infection can be performed using ultrasound, though a delay of 5 weeks following primary maternal infection is advised. A PCR (DNA) test of the mother's amniotic fluid can also be performed, though the risk of spontaneous abortion due to the amniocentesis procedure is higher than the risk of the baby's developing fetal varicella syndrome.[24]

Pathophysiology[edit]

Exposure to VZV in a healthy child initiates the production of host immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA) antibodies; IgG antibodies persist for life and confer immunity. Cell-mediated immune responses are also important in limiting the scope and the duration of primary varicella infection. After primary infection, VZV is hypothesized to spread from mucosal and epidermal lesions to local sensory nerves. VZV then remains latent in the dorsal ganglion cells of the sensory nerves. Reactivation of VZV results in the clinically distinct syndrome of herpes zoster (i.e., shingles), postherpetic neuralgia,[26] and sometimes Ramsay Hunt syndrome type II.[27] Varicella zoster can affect the arteries in the neck and head, producing stroke, either during childhood, or after a latency period of many years.[28]

Shingles[edit]

Main article: Herpes zoster

After a chickenpox infection, the virus remains dormant in the body's nerve tissues. The immune system keeps the virus at bay, but later in life, usually as an adult, it can be reactivated and cause a different form of the viral infection called shingles (also known as herpes zoster).[29] The United States Advisory Committee on Immunization Practices (ACIP) suggests that every adult over the age of 60 years get the herpes zoster vaccine.[30]

Shingles affects one in five adults infected with chickenpox as children, especially those who are immune suppressed, particularly from cancer, HIV, or other conditions. Stress can bring on shingles as well, although scientists are still researching the connection.[31] Shingles are most commonly found in adults over the age of 60 who were diagnosed with chickenpox when they were under the age of 1.[32]

Prevention[edit]

Hygiene measures[edit]

The spread of chickenpox can be prevented by isolating affected individuals. Contagion is by exposure to respiratory droplets, or direct contact with lesions, within a period lasting from three days before the onset of the rash, to four days after the onset of the rash.[33] The chickenpox virus is susceptible to disinfectants, notably chlorine bleach (i.e., sodium hypochlorite). Like all enveloped viruses, it is sensitive to desiccation, heat and detergents.

Vaccine[edit]

Main article: Varicella vaccine

The varicella vaccine is recommended in many countries.[8] Some countries require the varicella vaccination or an exemption before entering elementary school. A second dose is recommended five years after the initial immunization.[34] A vaccinated person is likely to have a milder case of chickenpox if they become infected.[35] Immunization within three days of exposure may improve outcomes in children.[9]

It is part of the routine immunization schedule in the US.[36] In the UK, the vaccine is currently only recommended in people who are particularly vulnerable to chickenpox.[35] Other European countries include it as part of universal vaccinations in children.[37] Not all countries provide the vaccine due to its cost.[8]

Treatment[edit]

Treatment mainly consists of easing the symptoms. As a protective measure, people are usually required to stay at home while they are infectious to avoid spreading the disease to others. Cutting the nails short or wearing gloves may prevent scratching and minimize the risk of secondary infections.

Although there have been no formal clinical studies evaluating the effectiveness of topical application of calamine lotion, a topical barrier preparation containing zinc oxide and one of the most commonly used interventions, it has an excellent safety profile.[38] It is important to maintain good hygiene and daily cleaning of skin with warm water to avoid secondary bacterial infection.[39] Scratching may also increase the risk of secondary infection.[40]

Paracetamol (acetaminophen) but not aspirin may be used to reduce fever. Aspirin use by someone with chickenpox may cause the serious, sometimes fatal disease of the liver and brain, Reye syndrome. People at risk of developing severe complications who have had significant exposure to the virus may be given intra-muscular varicella zoster immune globulin (VZIG), a preparation containing high titres of antibodies to varicella zoster virus, to ward off the disease.[41][42]

Antivirals are sometimes used.[43][44]

Children[edit]

If oral acyclovir is started within 24 hours of rash onset, it decreases symptoms by one day but has no effect on complication rates.[45][46] Use of acyclovir therefore is not currently recommended for individuals with normal immune function. Children younger than 12 years old and older than one month are not meant to receive antiviral medication unless they have another medical condition which puts them at risk of developing complications.[47]

Treatment of chickenpox in children is aimed at symptoms while the immune system deals with the virus. With children younger than 12 years, cutting nails and keeping them clean is an important part of treatment as they are more likely to scratch their blisters more deeply than adults.[48]

Aspirin is highly contraindicated in children younger than 16 years, as it has been related to Reye's syndrome.[49]

Adults[edit]

Infection in otherwise healthy adults tends to be more severe.[50] Treatment with antiviral drugs (e.g. acyclovir or valacyclovir) is generally advised, as long as it is started within 24–48 hours from rash onset.[47] Remedies to ease the symptoms of chickenpox in adults are basically the same as those used for children. Adults are more often prescribed antiviral medication, as it is effective in reducing the severity of the condition and the likelihood of developing complications. Antiviral medicines do not kill the virus but stop it from multiplying. Adults are advised to increase water intake to reduce dehydration and to relieve headaches. Painkillers such as paracetamol (acetaminophen) are recommended, as they are effective in relieving itching and other symptoms such as fever or pains. Antihistamines relieve itching and may be used in cases where the itching prevents sleep, because they are also sedative. As with children, antiviral medication is considered more useful for those adults who are more prone to develop complications. These include pregnant women or people who have a weakened immune system.[51]

Sorivudine, a nucleoside analogue, has been reported to be effective in the treatment of primary varicella in healthy adults (case reports only), but large-scale clinical trials are still needed to demonstrate its efficacy.[52]

After recovering from chickenpox, it is recommended by doctors that adults take one injection of VZV immune globulin and one injection of varicella vaccine or herpes zoster vaccine.[citation needed]

Prognosis[edit]

The duration of the visible blistering caused by varicella zoster virus varies in children usually from 4 to 7 days, and the appearance of new blisters begins to subside after the fifth day. Chickenpox infection is milder in young children, and symptomatic treatment, with sodium bicarbonate baths or antihistamine medication may ease itching. it is recommended to keep new infants from birth up to age 6 months away from an infected person for 10 to 21 days because their immune systems are not developed enough to handle the stress it can bring on.[53] Paracetamol (acetaminophen) is widely used to reduce fever. Aspirin, or products containing aspirin, should not be given to children with chickenpox, as it can cause Reye's Syndrome.[54]

In adults, the disease is more severe,[55] though the incidence is much less common. Infection in adults is associated with greater morbidity and mortality due to pneumonia (either direct viral pneumonia or secondary bacterial pneumonia),[56] bronchitis (either viral bronchitis or secondary bacterial bronchitis),[56] hepatitis,[57] and encephalitis.[58] In particular, up to 10% of pregnant women with chickenpox develop pneumonia, the severity of which increases with onset later in gestation. In England and Wales, 75% of deaths due to chickenpox are in adults.[24] Inflammation of the brain, or encephalitis, can occur in immunocompromised individuals, although the risk is higher with herpes zoster.[59] Necrotizing fasciitis is also a rare complication.[60]

Varicella can be lethal to adults with impaired immunity. The number of people in this high-risk group has increased, due to the HIV epidemic and the increased use of immunosuppressive therapies.[61] Varicella is a particular problem in hospitals, when there are patients with immune systems weakened by drugs (e.g., high-dose steroids) or HIV.[62]

Secondary bacterial infection of skin lesions, manifesting as impetigo, cellulitis, and erysipelas, is the most common complication in healthy children. Disseminated primary varicella infection usually seen in the immunocompromised may have high morbidity. Ninety percent of cases of varicella pneumonia occur in the adult population. Rarer complications of disseminated chickenpox include myocarditis, hepatitis, and glomerulonephritis.[63]

Hemorrhagic complications are more common in the immunocompromised or immunosuppressed populations, although healthy children and adults have been affected. Five major clinical syndromes have been described: febrile purpura, malignant chickenpox with purpura, postinfectious purpura, purpura fulminans, and anaphylactoid purpura. These syndromes have variable courses, with febrile purpura being the most benign of the syndromes and having an uncomplicated outcome. In contrast, malignant chickenpox with purpura is a grave clinical condition that has a mortality rate of greater than 70%. The cause of these hemorrhagic chickenpox syndromes is not known.[63]

Epidemiology[edit]

Primary varicella occurs in all countries worldwide. In 2013 the disease resulted in 7,000 deaths – down from 8,900 in 1990.[10]

In temperate countries, chickenpox is primarily a disease of children, with most cases occurring during the winter and spring, most likely due to school contact. It is one of the classic diseases of childhood, with the highest prevalence in the 4– 10-year-old age group. Like rubella, it is uncommon in preschool children. Varicella is highly communicable, with an infection rate of 90% in close contacts. In temperate countries, most people become infected before adulthood, and 10% of young adults remain susceptible.

In the tropics, chickenpox often occurs in older people and may cause more serious disease.[64] In adults, the pock marks are darker and the scars more prominent than in children.[65]

In the United States, the Centers for Disease Control and Prevention (CDC) does not require state health departments to report infections of chicken pox, and only 31 states currently volunteer this information.[66] However, in a 2013 study conducted by the social media disease surveillance tool called Sickweather, anecdotal reports of chickenpox infections on Facebook and Twitter were used to measure and rank states with the most infections per capita, with Maryland, Tennessee and Illinois in the top three.[67]

Etymology[edit]

Why the term was used is not clear but it may be due to it being a relatively mild disease.[11] It has been said to be derived from chickpeas, based on resemblance of the vesicles to chickpeas,[11][68][69] or to come from the rash resembling chicken pecks.[69] Other suggestions include the designation chicken for a child (i.e., literally 'child pox'), a corruption of itching-pox,[68][70] or the idea that the disease may have originated in chickens.[71] Samuel Johnson explained the designation as "from its being of no very great danger."[72]

Society and culture[edit]

Some parents believe that it is better for children to contract chickenpox than to get the vaccine, and they deliberately expose their children to the virus, sometimes by taking them to "chickenpox parties." Some doctors counter that children are safer getting the vaccine, which is a weakened form of the virus, than getting the disease, which can be fatal.[73]

Other animals[edit]

Humans are the only known animal that the disease affects naturally.[4] However, chickenpox has been caused in other primates, including chimpanzees[74] and gorillas.[75]

References[edit]

  1. ^ "Chickenpox (Varicella) Overview". cdc.gov. November 16, 2011. Retrieved 4 February 2015. 
  2. ^ a b c d "Chickenpox (Varicella) Signs & Symptoms". http://www.cdc.gov/. November 16, 2011. Retrieved 4 February 2015. 
  3. ^ "Chickenpox (Varicella) Complications". cdc.gov. November 16, 2011. Retrieved 4 February 2015. 
  4. ^ a b c d e f g h i j k Atkinson, William (2011). Epidemiology and Prevention of Vaccine-Preventable Diseases (12 ed.). Public Health Foundation. pp. 301–323. ISBN 9780983263135. Retrieved 4 February 2015. 
  5. ^ a b c d e f g h "Chickenpox (Varicella) Transmission". cdc.gov. November 16, 2011. Retrieved 4 February 2015. 
  6. ^ "Chickenpox (Varicella) Interpreting Laboratory Tests". cdc.gov. June 19, 2012. Retrieved 4 February 2015. 
  7. ^ "Routine vaccination against chickenpox?". Drug Ther Bull 4 (50): 42–5. 2012. doi:10.1136/dtb.2012.04.0098. PMID 22495050. 
  8. ^ a b c Flatt, A; Breuer, J (September 2012). "Varicella vaccines.". British medical bulletin 103 (1): 115–27. doi:10.1093/bmb/lds019. PMID 22859715. 
  9. ^ a b Macartney, K; Heywood, A; McIntyre, P (23 June 2014). "Vaccines for post-exposure prophylaxis against varicella (chickenpox) in children and adults.". The Cochrane database of systematic reviews 6: CD001833. doi:10.1002/14651858.CD001833.pub3. PMID 24954057. 
  10. ^ a b GBD 2013 Mortality and Causes of Death, Collaborators (17 December 2014). "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.". Lancet 385 (9963): 117–71. doi:10.1016/S0140-6736(14)61682-2. PMC 4340604. PMID 25530442. 
  11. ^ a b c d Oxford University Press (December 2014). "chickenpox, n.". oed.com. Retrieved February 4, 2015. 
  12. ^ a b Anthony J Papadopoulos. Dirk M Elston, ed. "Chickenpox Clinical Presentation". Medscape Reference. Retrieved 4 August 2012. 
  13. ^ "Symptoms of Chickenpox". Chickenpox. NHS Choices. Retrieved 14 March 2013. 
  14. ^ "Chickenpox (varicella)". Retrieved 6 November 2010. 
  15. ^ "Varicella Zoster Virus". Retrieved 6 November 2010. 
  16. ^ Askalan R, Laughlin S, Mayank S, Chan A, MacGregor D, Andrew M, Curtis R, Meaney B, deVeber G (June 2001). "Chickenpox and stroke in childhood: a study of frequency and causation". Stroke 32 (6): 1257–62. doi:10.1161/01.STR.32.6.1257. PMID 11387484. 
  17. ^ Heuchan AM, Isaacs D (19 March 2001). "The management of varicella-zoster virus exposure and infection in pregnancy and the newborn period. Australasian Subgroup in Paediatric Infectious Diseases of the Australasian Society for Infectious Diseases.". The Medical journal of Australia 174 (6): 288–92. PMID 11297117. 
  18. ^ Brannon, Heather (22 July 2007). "Chickenpox in Pregnanc". Dermatology. About.com. Retrieved 20 June 2009. 
  19. ^ "Chickenpox During Pregnancy". March of Dimes. November 11, 2014. 
  20. ^ Boussault P, Boralevi F, Labbe L, Sarlangue J, Taïeb A, Leaute-Labreze C (2007). "Chronic varicella-zoster skin infection complicating the congenital varicella syndrome". Pediatr Dermatol 24 (4): 429–32. doi:10.1111/j.1525-1470.2007.00471.x. PMID 17845179. 
  21. ^ Matsuo T, Koyama M, Matsuo N (July 1990). "Acute retinal necrosis as a novel complication of chickenpox in adults". Br J Ophthalmol 74 (7): 443–4. doi:10.1136/bjo.74.7.443. PMC 1042160. PMID 2378860. 
  22. ^ Mazzella M, Arioni C, Bellini C, Allegri AE, Savioli C, Serra G (2003). "Severe hydrocephalus associated with congenital varicella syndrome". CMAJ: Canadian Medical Association journal = journal de l'Association medicale canadienne 168 (5): 561–563. PMC 149248. PMID 12615748. 
  23. ^ Sauerbrei A, Wutzler P (December 2001). "Neonatal varicella". J Perinatol 21 (8): 545–9. doi:10.1038/sj.jp.7210599. PMID 11774017. 
  24. ^ a b c Royal College of Obstetricians and Gynaecologists (September 2007). "Chickenpox in Pregnancy" (PDF). Retrieved 22 July 2009. 
  25. ^ Pincus, Matthew R.; McPherson, Richard A.; Henry, John Bernard (2007). "Ch. 54". Henry's clinical diagnosis and management by laboratory methods (21st ed.). Saunders Elsevier. ISBN 1-4160-0287-1. 
  26. ^ Kanbayashi Y, Onishi K, Fukazawa K, Okamoto K, Ueno H, Takagi T, Hosokawa T (2012). "Predictive Factors for Postherpetic Neuralgia Using Ordered Logistic Regression Analysis". The Clinical Journal of Pain 28 (8): 712–714. doi:10.1097/AJP.0b013e318243ee01. PMID 22209800. 
  27. ^ Pino Rivero V, González Palomino A, Pantoja Hernández CG, Mora Santos ME, Trinidad Ramos G, Blasco Huelva A (2006). "Ramsay-Hunt syndrome associated to unilateral recurrential paralysis". Anales otorrinolaringologicos ibero-americanos 33 (5): 489–494. PMID 17091862. 
  28. ^ "The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features.". Neurology. March 2008. 
  29. ^ "Chickenpox". NHS Choices. UK Department of Health. 19 April 2012. 
  30. ^ "Shingles Vaccine". WebMD. 
  31. ^ "An Overview of Shingles". WebMD. 
  32. ^ "Shingles". PubMed Health. 
  33. ^ Murray, Patrick R.; Rosenthal, Ken S.; Pfaller, Michael A. (2005). Medical Microbiology (5th ed.). Elsevier Mosby. p. 551. ISBN 0-323-03303-2. , edition (Elsevier), p.
  34. ^ Chaves SS, Gargiullo P, Zhang JX, Civen R, Guris D, Mascola L, Seward JF (2007). "Loss of vaccine-induced immunity to varicella over time". N Engl J Med 356 (11): 1121–9. doi:10.1056/NEJMoa064040. PMID 17360990. 
  35. ^ a b "Chickenpox (varicella) vaccination". NHS Choices. UK Department of Health. 19 April 2012. 
  36. ^ "Child, Adolescent & "Catch-up" Immunization Schedules". Immunization Schedules. Centers for Disease Control and Prevention. 
  37. ^ Carrillo-Santisteve, P; Lopalco, PL (May 2014). "Varicella vaccination: a laboured take-off.". Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 20 Suppl 5: 86–91. doi:10.1111/1469-0691.12580. PMID 24494784. 
  38. ^ Tebruegge M, Kuruvilla M, Margarson I (2006). "Does the use of calamine or antihistamine provide symptomatic relief from pruritus in children with varicella zoster infection?" (ABSTRACT). Arch. Dis. Child. 91 (12): 1035–6. doi:10.1136/adc.2006.105114. PMC 2082986. PMID 17119083. 
  39. ^ Domino, Frank J. (2007). The 5-Minute Clinical Consult. Lippincott Williams & Wilkins. p. 248. ISBN 978-0-7817-6334-9. 
  40. ^ Brannon, Heather (21 May 2008). Chicken Pox Treatments. About.com.
  41. ^ Parmet S, Lynm C, Glass RM (February 2004). "JAMA patient page. Chickenpox". JAMA 291 (7): 906. doi:10.1001/jama.291.7.906. PMID 14970070. 
  42. ^ Naus M et al. (15 October 2006). "Varizig™ as the Varicella Zoster Immune Globulin for the Prevention of Varicella In At-Risk Patients". Canada Communicable Disease Report 32 (ACS-8). 
  43. ^ Huff JC (January 1988). "Antiviral treatment in chickenpox and herpes zoster.". Journal of the American Academy of Dermatology 18 (1 Pt 2): 204–6. doi:10.1016/S0190-9622(88)70029-8. PMID 3339143. 
  44. ^ Gnann Jr, John W. (2007). "Chapter 65Antiviral therapy of varicella-zoster virus infections". In Arvin, Ann; et.al. Human herpesviruses : biology, therapy, and immunoprophylaxis. Cambridge: Cambridge University Press. ISBN 978-0-521-82714-0. Retrieved 20 January 2014. 
  45. ^ Kay, A. B. (2001). "Allergy and allergic diseases. First of two parts". The New England Journal of Medicine 344 (1): 30–7. doi:10.1056/NEJM200101043440106. PMID 11136958. 
  46. ^ Kay, A. B. (2001). "Allergy and allergic diseases. Second of two parts". The New England Journal of Medicine 344 (2): 109–13. doi:10.1056/NEJM200101113440206. PMID 11150362. 
  47. ^ a b "Antiviral medications for chickenpox". Retrieved 27 March 2011. 
  48. ^ "Chickenpox in Children Under 12". Retrieved 6 November 2010. 
  49. ^ "Reye's Syndrome-Topic Overview". Retrieved 27 March 2011. 
  50. ^ Tunbridge AJ, Breuer J, Jeffery KJ (August 2008). "Chickenpox in adults - clinical management". The Journal of Infection 57 (2): 95–102. doi:10.1016/j.jinf.2008.03.004. PMID 18555533. 
  51. ^ "What is chickenpox?". Retrieved 6 November 2010. 
  52. ^ Chickenpox~treatment at eMedicine
  53. ^ Somekh E, Dalal I, Shohat T, Ginsberg GM, Romano O (2002). "The burden of uncomplicated cases of chickenpox in Israel". J. Infect. 45 (1): 54–7. doi:10.1053/jinf.2002.0977. PMID 12217733. 
  54. ^ US Centers for Disease Control and Prevention. "Varicella Treatment Questions & Answers". CDC Guidelines. CDC. Retrieved 23 August 2007. 
  55. ^ Baren JM, Henneman PL, Lewis RJ (August 1996). "Primary Varicella in Adults: Pneumonia, Pregnancy, and Hospital Admissions". Annals of Emergency Medicine 28 (2): 165–169. doi:10.1016/S0196-0644(96)70057-4. PMID 8759580. 
  56. ^ a b Mohsen AH, McKendrick M (May 2003). "Varicella pneumonia in adults". Eur. Respir. J. 21 (5): 886–91. doi:10.1183/09031936.03.00103202. PMID 12765439. 
  57. ^ Anderson, D.R.; Schwartz, J.; Hunter, N.J.; Cottrill, C.; Bissaccia, E.; Klainer, A.S. (1994). "Varicella Hepatitis: A Fatal Case in a Previously Healthy, Immunocompetent Adult". Archives of Internal Medicine (JAMA) 154 (18): 2101–2106. doi:10.1001/archinte.1994.00420180111013. PMID 8092915. 
  58. ^ Abro AH, Ustadi AM, Das K, Abdou AM, Hussaini HS, Chandra FS (December 2009). "Chickenpox: presentation and complications in adults". Journal of Pakistan Medical Association 59 (12): 828–831. PMID 20201174. Retrieved 17 April 2013. 
  59. ^ "Definition of Chickenpox". MedicineNet.com. Retrieved 18 August 2006. 
  60. ^ "Is Necrotizing Fasciitis a complication of Chickenpox of Cutaneous Vasculitis?". atmedstu.com. Retrieved 18 January 2008. 
  61. ^ Strangfeld A, Listing J, Herzer P, Liebhaber A, Rockwitz K, Richter C, Zink A (February 2009). "Risk of herpes zoster in patients with rheumatoid arthritis treated with anti-TNF-alpha agents". JAMA 301 (7): 737–44. doi:10.1001/jama.2009.146. PMID 19224750. 
  62. ^ Weller TH (1997). "Varicella-herpes zoster virus". In Evans AS, Kaslow RA. Viral Infections of Humans: Epidemiology and Control. Plenum Press. pp. 865–92. ISBN 978-0-306-44855-3. 
  63. ^ a b Chicken Pox Complications
  64. ^ Wharton M (1996). "The epidemiology of varicella-zoster virus infections". Infect Dis Clin North Am 10 (3): 571–81. doi:10.1016/S0891-5520(05)70313-5. PMID 8856352. 
  65. ^ "Epidemiology of Varicella Zoster Virus Infection, Epidemiology of VZV Infection, Epidemiology of Chicken Pox, Epidemiology of Shingles". Retrieved 22 April 2008. 
  66. ^ "Georgia ranks 10th for social media admissions of chickenpox". Retrieved 13 June 2013. 
  67. ^ "Chickenpox in the USA". Retrieved 12 June 2013. 
  68. ^ a b Belshe, Robert B. (1984). Textbook of human virology (2nd ed.). Littleton MA: PSG. p. 829. ISBN 0-88416-458-6. 
  69. ^ a b Teri Shors (2011). "Herpesviruses: Varicella Zoster Virus (VZV)". Understanding Viruses (2nd ed.). Jones & Bartlett. p. 459. ISBN 978-0-7637-8553-6. 
  70. ^ Pattison, John; Zuckerman, Arie J.; Banatvala, J.E. (1994). Principles and practice of clinical virology (3rd ed.). Wiley. p. 37. ISBN 0-471-93106-3. 
  71. ^ Chicken-pox is recorded in Oxford English Dictionary 2nd ed. since 1684; the OED records several suggested etymologies
  72. ^ Johnson, Samuel (1839). Dictionary of the English language. London: Williamson. p. 195. 
  73. ^ "Chicken Pox parties do more harm than good, says doctor". KSLA News 12 Shreveport, Louisiana News Weather & Sports. 
  74. ^ Cohen JI, Moskal T, Shapiro M, Purcell RH (December 1996). "Varicella in Chimpanzees". Journal of Medical Virology 50 (4): 289–92. doi:10.1002/(SICI)1096-9071(199612)50:4<289::AID-JMV2>3.0.CO;2-4. PMID 8950684. 
  75. ^ Myers MG, Kramer LW, Stanberry LR (December 1987). "Varicella in a gorilla". Journal of Medical Virology 23 (4): 317–22. doi:10.1002/jmv.1890230403. PMID 2826674. 

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