Children's Medical Research Institute
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The Children's Medical Research Institute (CMRI) is an Australian based independent scientific research organisation created in 1958 by Paediatricians Sir Lorimer Dods and Dr John Fulton and Douglas Burrows, honorary treasurer and later president of the Royal Alexandra Hospital for Children, to "perform scientific research with a commitment to better treat, and where possible, prevent childhood illness and disability so that all concerned have a better quality of life". The Institute is the organiser of Australia's annual Jeans for Genes campaign.
The CMRI conducts research into the fundamental causes of disease, current research is focussed on cancer, epilepsy and birth defects.
Recently, the Institute joined with the University of Newcastle to establish a Chemical Proteomics Centre for Kinomics (CFK) - a new discipline not yet available in Australia. This new centre, also a world-first, is supported by a $3.1 million grant awarded in 2009 by the Australian Cancer Research Foundation.
Cancer Research Unit
Cell Biology Unit
Cell Cycle Unit
Cell Signalling Unit
Gene Therapy Research Unit
In March 2007, Dr Scott Cohen and his team made a significant discovery in telomerase research by establishing that the enzyme consists of two molecules each of telomerase reverse transcriptase, telomerase RNA, and dyskerin.
In 1995 CMRI researcher Prof Roger Reddel and team discovered ALT (Alternative lengthening of telomeres), a method by which approximately 15% of human cancer cells achieve ‘immortality’ and keep dividing. This work is being pursued with a focus on understanding ALT and developing potential anti-cancer treatments and diagnostic tools.
Found a single genetic defect can cause cleft lip and palate
Fate map of the early embryo to help us understand many developmental problems
Identification of the components of telomerase, which will be important for treating 85% of all cancers
Discovery of the Alternative Lengthening of Telomeres (ALT) mechanism, which will lead to treatments for the other 15% of cancers
Developing a blood test for ALT cancers that will allow physicians to diagnose and plan treatments for cancers such as aggressive glioblastoma brain tumours
Partnering with The Children’s Hospital at Westmead on a cure for genetic liver disease, with clinical trials about to begin
Discovering and developing a new class of drugs for treating epilepsy
- Yu, John, 'Dods, Sir Lorimer Fenton (1900–1981)', Australian Dictionary of Biography, National Centre of Biography, Australian National University, http://adb.anu.edu.au/biography/dods-sir-lorimer-fenton-12426/text22341, accessed 11 August 2012
- Chemical Proteomics Centre for Kinomics, Australian Cancer Research Foundation.
- CMRI's official website
- Jeans for Genes Australia website
- Australian Cancer Research Foundation website
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