Chimerin 2

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Chimerin 2
Protein CHN2 PDB 1xa6.png
PDB rendering based on 1xa6.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CHN2 ; ARHGAP3; BCH; CHN2-3; RHOGAP3
External IDs OMIM602857 MGI1917243 HomoloGene31213 ChEMBL: 4504 GeneCards: CHN2 Gene
RNA expression pattern
PBB GE CHN2 213385 at tn.png
PBB GE CHN2 207486 x at tn.png
PBB GE CHN2 211419 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1124 69993
Ensembl ENSG00000106069 ENSMUSG00000004633
UniProt P52757 Q80XD1
RefSeq (mRNA) NM_001039936 NM_001163640
RefSeq (protein) NP_001035025 NP_001157112
Location (UCSC) Chr 7:
29.16 – 29.55 Mb
Chr 6:
54.04 – 54.3 Mb
PubMed search [1] [2]

Beta-chimaerin is a protein that in humans is encoded by the CHN2 gene.[1][2]

This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

References[edit]

  1. ^ Leung T, How BE, Manser E, Lim L (Jun 1994). "Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain". J Biol Chem 269 (17): 12888–92. PMID 8175705. 
  2. ^ a b "Entrez Gene: CHN2 chimerin (chimaerin) 2". 

Further reading[edit]