Chloramphenicol phosphotransferase-like protein family

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Chloramphenicol phosphotransferase-like protein
PDB 1zp6 EBI.jpg
crystal structure of atu3015, a putative cytidylate kinase from agrobacterium tumefaciens, northeast structural genomics target atr62
Identifiers
Symbol CPT
Pfam PF07931
Pfam clan CL0023
InterPro IPR012853
SCOP 1grq
SUPERFAMILY 1grq
CDD cd00227

In molecular biology, the chloramphenicol phosphotransferase-like protein family includes the chloramphenicol 3-O phosphotransferase (CPT) expressed by Streptomyces venezuelae. Chloramphenicol (Cm) is a metabolite produced by this bacterium that can inhibit ribosomal peptidyl transferase activity and therefore protein production. By transferring a phosphate group to the C-3 hydroxyl group of Cm, CPT inactivates this potentially lethal metabolite.[1][2]

References[edit]

This article incorporates text from the public domain Pfam and InterPro IPR012853