Chloramphenicol phosphotransferase-like protein family

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Chloramphenicol phosphotransferase-like protein
PDB 1zp6 EBI.jpg
crystal structure of atu3015, a putative cytidylate kinase from agrobacterium tumefaciens, northeast structural genomics target atr62
Symbol CPT
Pfam PF07931
Pfam clan CL0023
InterPro IPR012853
SCOP 1grq
CDD cd00227

In molecular biology, the chloramphenicol phosphotransferase-like protein family includes the chloramphenicol 3-O phosphotransferase (CPT) expressed by Streptomyces venezuelae. Chloramphenicol (Cm) is a metabolite produced by this bacterium that can inhibit ribosomal peptidyl transferase activity and therefore protein production. By transferring a phosphate group to the C-3 hydroxyl group of Cm, CPT inactivates this potentially lethal metabolite.[1][2]


This article incorporates text from the public domain Pfam and InterPro IPR012853