Chlorcyclizine

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Chlorcyclizine
Chlorcyclizine.png
Systematic (IUPAC) name
1-[(4-chlorophenyl)(phenyl)methyl]-4-methylpiperazine
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a682619
Legal status
  • Prescription only
Routes Oral
Identifiers
CAS number 82-93-9
ATC code R06AE04
PubChem CID 2710
ChemSpider 2609 YesY
UNII M26C4IP44P YesY
ChEMBL CHEMBL22150 YesY
Chemical data
Formula C18H21ClN2 
Mol. mass 300.826 g/mol
 YesY (what is this?)  (verify)

Chlorcyclizine (Di-Paralene, Mantadil, Pruresidine, Trihistan) is a first-generation antihistamine of the phenylpiperazine class marketed in the United States and certain other countries.[1][2][3] It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic.[1][2][3] In addition to its antihistamine effects, chlorcyclizine also has some anticholinergic, antiserotonergic, and local anesthetic properties.[4][5]

See also[edit]

References[edit]

  1. ^ a b Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. 
  2. ^ a b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. 
  3. ^ a b Hall, Judith A.; Morton, Ian (1999). Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic. ISBN 0-7514-0499-3. 
  4. ^ Dorland Staff (2008). Dorland Dictionnaire Medical Bilingue Francais-anglais / Anglais-francais: + E-book a Telecharger (French Edition). Elsevier (Educa Books). ISBN 2-84299-899-5. 
  5. ^ Rogóz Z, Skuza G, Sowińska H (November 1981). "The effect of the antihistaminic drugs on the central action of 5-hydroxytryptophan in mice". Polish Journal of Pharmacology and Pharmacy 33 (4): 459–65. PMID 6120505.