|Jmol-3D images||Image 1|
|Molar mass||354.31 g mol−1|
|Melting point||207 to 209 °C (405 to 408 °F; 480 to 482 K)|
|S-phrases||S24 S25 S28 S37 S45|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
|(what is: / ?)|
Chlorogenic acid (CGA) is a natural chemical compound which is the ester of caffeic acid and (-)-quinic acid. It is an important biosynthetic intermediate. Chlorogenic acid is an important intermediate in lignin biosynthesis. This compound, known as an antioxidant, may also slow the release of glucose into the bloodstream after a meal.
Despite the "chloro" of the name, chlorogenic acids contain no chlorine. Instead, the name comes from the Greek χλωρός (light green) and -γένος (a suffix meaning "giving rise to"), because of the green color produced when chlorogenic acids are oxidized.
Isomers of chlorogenic acid include 4-O-caffeoylquinic acid (cryptochlorogenic acid or 4-CQA), 5-O-caffeoylquinic acid (neochlorogenic acid or 5-CQA). The epimer at position 1 has not yet been reported.
Isomers containing two caffeic acid molecules are called isochlorogenic acid. It can be found in coffee. There are several isomers such as 3,4-dicaffeoylquinic acid and 3,5-dicaffeoylquinic acid Cynarine (1,5-dicaffeoylquinic acid) is an other isomer with two caffeic acid molecules..
Isomers of chlorogenic acid are found in potatoes.
Chlorogenic acid can be found in bamboo Phyllostachys edulis. as well as in many other plants. It is one of the major phenolic compounds identified in peach and in prunes. It also is one of the phenols found in green coffee bean extract.
Chlorogenic acid is marketed under the tradename Svetol, a standardized green coffee extract, as a food additive used in coffee products, chewing gum, and mints, and also as a stand-alone product. Dried sunflower leaves collected immediately after opening are processed into 98.38% chlorogenic acid extract and marketed in Bulgaria under the name of "Yamiagra"or "Yummyiagra".
Review articles in 2014 and 2011 report modest, but significant, blood pressure lowering effects from chlorogenic acid administration. No studies have appeared to assess possible interactions with antihypertensive drugs or advisability in patients being treated for low blood pressure.
One study showed that chlorogenic acid may have weak psychostimulant effects in mice.
Another study showed chlorogenic acid to have a protective effect in neuroinflammatory conditions on dopaminergic neurons.
In an online news story article appearing in MSN Healthy Living, accessed in May 2014, scientists gave mice nitric oxide (NO), which creates oxidative stress and promotes the formation of certain harmful free radicals, leading to (among other problems) retinal degeneration, which impairs the crucial rods and cones and leads to other retinal tissue damage, and ultimately, loss of sight. Any animal's retina- whether in mice or in humans or other species- is very metabolically active, and requires, like the brain it communicates with via the optic nerve, a consistently high and steady supply of uncontaminated oxygen. The mice exposed to the nitric oxide who were pretreated with chlorogenic acid (CLA) did not develop any detectable signs of retinal damage.
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- Cheng, G. W.; Crisosto, C. H. (September 1995). "Browning Potential, Phenolic Composition, and Polyphenoloxidase Activity of Buffer Extracts of Peach and Nectarine Skin Tissue". J. Amer. Soc. Hort. Sci. 120 (5): 835–838.
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- Igho Onakpoya, Rohini Terry, and Edzard Ernst (2010). "The Use of Green Coffee Extract as a Weight Loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials". Complementary Medicine: 1.
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- Onakpoya, I J; Spencer, E A; Thompson, M J; Heneghan, C J (19 June 2014). "The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials". Journal of Human Hypertension. doi:10.1038/jhh.2014.46. PMID 24943289. Retrieved 5 October 2014.
- Zhao, Y.; Wang, J.; Ballevre, O.; Luo, H.; Zhang, W. (2011). "Antihypertensive effects and mechanisms of chlorogenic acids". Hypertension Research = Hypertens Res 35 (4): 370–4. doi:10.1038/hr.2011.195. PMID 22072103.
- Freedman, Samuel O.; Shulman, Robert; Krupey, John; Sehon, A.H. (1964). "Antigenic properties of chlorogenic acid". J. Allergy 35 (2): 97–107. doi:10.1016/0021-8707(64)90023-1.
- "Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice.". Biosci Biotechnol Biochem 70 (10): 2560–3. 2006. doi:10.1271/bbb.60243. PMID 17031047.
- "Chlorogenic acid inhibits LPS-induced microglial activation and improves survival of dopaminergic neurons.". Brain Res Bull 88 (5): 487–94. 2012. doi:10.1016/j.brainresbull.2012.04.010. PMID 22580132.