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Abbreviations CHPG
CAS number 170846-74-9 YesY, 1303993-73-8 (sodium salt) YesY
PubChem 3645780
ChemSpider 2879711
Jmol-3D images Image 1
Molecular formula C8H6ClNO3
Molar mass 199.59 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

2-Chloro-5-hydroxyphenylglycine or CHPG is an agonist of the metabotropic glutamate receptors, specific for mGluR5.[1]

It is capable of directly potentiating the depolarization of hippocampal CA1 neurons induced through NMDA administration.[2]


  1. ^ Kammermeier, Paul J (2012). "The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency". BMC Pharmacology 12: 6. doi:10.1186/1471-2210-12-6. PMC 3416681. PMID 22642439. 
  2. ^ Collingridge G.; Volianskis A.; Bannister N.; France G.; Hanna L.; Mercier M.; Tidball P.; Fang G.; Irvine M.; Costa, Blaise M.; Monaghan, Daniel T.; Bortolotto, Zuner A.; Molnár, Elek; Lodge, David; Jane, David E. (2013). "The NMDA receptor as a target for cognitive enhancement". Neuropharmacology 64: 13–26. doi:10.1016/j.neuropharm.2012.06.051. PMID 22796429.