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Kekulé, skeletal formula of chloroxylenol
Systematic IUPAC name
ATC code D08AE05
88-04-0 YesY
ChemSpider 21106017 YesY
EC number 201-793-8
Jmol-3D images Image
KEGG D03473 YesY
MeSH chloroxylenol
PubChem 2723
RTECS number ZE6850000
UNII 0F32U78V2Q YesY
Molar mass 156.61 g·mol−1
Melting point 114 °C (237 °F; 387 K)
log P 3.377
Acidity (pKa) 9.76
Basicity (pKb) 4.24
GHS pictograms The exclamation-mark pictogram in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
GHS signal word WARNING
H302, H315, H317, H319
P280, P305+351+338
EU Index 604-038-00-4
EU classification Harmful Xn
R-phrases R22, R36/38, R43
S-phrases (S2), S24, S37
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Chloroxylenol (4-chloro-3,5-dimethylphenol) is a broad spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus. It is used in hospitals and households for disinfection and sanitation.[2] It is also commonly used in antibacterial soaps, wound-cleansing applications and household antiseptics such as Dettol liquid, cream and ointments.[3] Studies have shown an anti microbial activity which is enhanced by additives. Its antibacterial action is due to disruption of cell membrane potentials.[4] Developed in Europe in the 1920s and used in the United States since the 1950s, Chloroxylenol is one of the most mature anti microbial agents.[5]

Chloroxylenol is not significantly toxic to humans and other mammals, is practically non-toxic to birds, moderately toxic to freshwater invertebrates and highly toxic to fish.[2] It is a mild skin irritant and may trigger allergic reactions in some individuals.


  1. ^ "chloroxylenol – Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification and Related Records. Retrieved 7 October 2011. 
  2. ^ a b
  3. ^ Ascenzi, Joseph M. (1996). "Chloroxylenol: an old-new antimicrobial". Handbook of disinfectants and antiseptics. New York: M. Dekker. ISBN 978-0-8247-9524-5. 
  4. ^ Aly, R; Malbach, H (1988). "Comparative antibacterial efficacy of a 2-minute surgical scrub with chlorhexidine gluconate, povidone-iodine, and chloroxylenol sponge-brushes". American Journal of Infection Control 16 (4): 173–7. doi:10.1016/0196-6553(88)90029-6. PMID 3189943. 
  5. ^ Larson, E (1986). "An approach for selection of health care personnel handwashing agents". Infect Control 7: 419–424. 

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