Cho Aniki Zero(零・超兄貴,Zero Chō Aniki?, lit. "Zero Super Big Brother") is a horizontally scrolling shoot 'em up, the latest game in the Cho Aniki series. It was published in Japan by GungHo Works on 19 March 2009 for the PlayStation Portable. The game was published in North America by Aksys Games on 25 March 2010 as a digital download exclusive for the PSP, with the full title of Cho Aniki Zero: Muscle Brothers. This makes it the second Cho Aniki title to be released in North America, following the Virtual Console port of the original game. It is the first Cho Aniki title developed by extreme Co., Ltd., who had obtained the rights of original developers NCS Corp. and Masaya products. The graphics followed the 3D appearance of the PS2 game.
A limited edition was released in Japan, which includes a soundtrack CD. Also released was a demo that included the first stage of the game.