Choline transporter

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Solute carrier family 5 (choline transporter), member 7
Symbols SLC5A7 ; CHT; CHT1; HMN7A; hCHT
External IDs OMIM608761 HomoloGene32516 IUPHAR: 914 GeneCards: SLC5A7 Gene
Species Human Mouse
Entrez 60482 63993
Ensembl ENSG00000115665 ENSMUSG00000023945
UniProt Q9GZV3 Q8BGY9
RefSeq (mRNA) NM_021815 NM_022025
RefSeq (protein) NP_068587 NP_071308
Location (UCSC) Chr 2:
108.6 – 108.63 Mb
Chr 17:
54.27 – 54.3 Mb
PubMed search [1] [2]

The high-affinity choline transporter (ChT) also known as solute carrier family 5 member 7 is a protein in humans that is encoded by the SLC5A7 gene.[1] It is a plasmalemmal transporter and carries choline into acetylcholine-synthesizing neurons.

Hemicholinium-3 is an inhibitor of the ChT and can be used to deplete acetylcholine stores, while coluracetam is an enhancer of the ChT and can increase cholinergic neurotransmission by enhancing acetylcholine synthesis.


Choline is a direct precursor of acetylcholine (ACh), a neurotransmitter of the central and peripheral nervous system that regulates a variety of autonomic, cognitive, and motor functions. SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons.[1][2]

Mutations in the SLC5A7 gene have been associated with Distal spinal muscular atrophy with vocal cord paralysis (distal hereditary motor neuropathy type 7A).[3]

See also[edit]


  1. ^ a b "Entrez Gene: Solute carrier family 5 (choline transporter), member 7". 
  2. ^ Apparsundaram S, Ferguson SM, George AL, Blakely RD (October 2000). "Molecular cloning of a human, hemicholinium-3-sensitive choline transporter". Biochem. Biophys. Res. Commun. 276 (3): 862–7. doi:10.1006/bbrc.2000.3561. PMID 11027560. 
  3. ^ Barwick, K. E. S.; Wright, J.; Al-Turki, S.; McEntagart, M. M.; Nair, A.; Chioza, B.; Al-Memar, A.; Modarres, H.; Reilly, M. M.; Dick, K. J.; Ruggiero, A. M.; Blakely, R. D.; Hurles, M. E.; Crosby, A. H. (2012). "Defective Presynaptic Choline Transport Underlies Hereditary Motor Neuropathy". The American Journal of Human Genetics 91 (6): 1103. doi:10.1016/j.ajhg.2012.09.019.  edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.