As well as being the founding (and only constant) member of influential desert rock outfit Masters of Reality, Goss is also well known for his production work on albums by Kyuss and Queens of the Stone Age. Largely credited as the Godfather of desert rock, Goss has on several occasions played down the importance of his role in this musical movement. In 1999 he stated:
I can't make any claim at all to inventing desert rock, or stoner rock, or whatever you want to call it. I make rock n roll records, and hopefully try to make the listener feel like I did when I heard my favourite music.
In 2004, Goss highlighted exactly what kind of music he created:
There’s a bunch of weirdos that I work with all the time, and we make what I call "out of whack" Rock records. That’s what I do. When people want an "out of whack" weird Rock record, they call me, and I take an "out of whack" amount of money to do it, and I’m glad to be there. It’s cool.
Goss appeared with his long time friend Josh Homme of Queens of the Stone Age as "The 5:15ers" at the "winter edition" of ArthurFest, performing an intimate set which was "crafted in less than a month as the duo was a rather late addition to the Arthurball line-up as Sunday's headliner". Continuing with Goon Moon, Goss, White and Hill released a full length album in May 2007 entitled Licker's Last Leg containing many guest artists synonymous with the desert rock scene.