Chris Ponting

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Chris Ponting
Chris Ponting.jpg
Born Christopher Paul Ponting
Residence England
Nationality British
Institutions University of Oxford
Alma mater University of Oxford
University of British Columbia
Thesis Structural Studies of Plasminogen and Related Proteins (1992)
Doctoral students
Known for SMART[1]

Christopher Paul Ponting is a British computational biologist, specializing in the evolution and function of genes and genomes. He is currently Professor of Genomics at the University of Oxford and group leader in the MRC Functional Genomics Unit, and is affiliated with the Oxford Centre for Gene Function, and Oxford's Department of Physiology, Anatomy and Genetics.[2][3][4][5][6]


After receiving his Bachelor of Arts and Master of Science in physics from University of Oxford and the University of British Columbia, respectively, he returned to Oxford, completing his Doctor of Philosophy in biophysics in 1991 while studying plasminogen.[7]


Ponting contributed to the Human Genome Project,[8] and did much of the sequence comparison for the mouse,[9] rat,[10] chicken,[11] dog,[12] opossum,[13] and platypus[14][15][16] Genome Projects. He has also used comparative genomics to contribute directly to the understanding of chromatin structure[17] and the genetics of numerous conditions including asthma,[18] obesity,[19] Alzheimer's disease,[20] retinitis pigmentosa,[21] muscular dystrophies,[22] and Aicardi-Goutières syndrome.[23]


  1. ^ Schultz, J.; Milpetz, F.; Bork, P.; Ponting, C. (1998). "SMART, a simple modular architecture research tool: Identification of signaling domains". Proceedings of the National Academy of Sciences of the United States of America 95 (11): 5857–5864. Bibcode:1998PNAS...95.5857S. doi:10.1073/pnas.95.11.5857. PMC 34487. PMID 9600884. 
  2. ^ Chris Ponting from the Scopus bibliographic database.
  3. ^ Sims, David (2014). "Sequencing depth and coverage: key considerations in genomic analyses". Nature Reviews Genetics 15 (2): 121–132. doi:10.1038/nrg3642. 
  4. ^ Rands, Chris M. (2014). "8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage". PLoS Genetics 10 (7): e1004525. doi:10.1371/journal.pgen.1004525. 
  5. ^ Gibbs, R. A.; Weinstock, G. M.; Metzker, M. L.; Muzny, D. M.; Sodergren, E. J.; Scherer, S; Scott, G; Steffen, D; Worley, K. C.; Burch, P. E.; Okwuonu, G; Hines, S; Lewis, L; Deramo, C; Delgado, O; Dugan-Rocha, S; Miner, G; Morgan, M; Hawes, A; Gill, R; Holt, R. A.; Adams, M. D.; Amanatides, P. G.; Baden-Tillson, H; Barnstead, M; Chin, S; Evans, C. A.; Ferriera, S; Fosler, C (2004). "Genome sequence of the Brown Norway rat yields insights into mammalian evolution". Nature 428 (6982): 493–521. doi:10.1038/nature02426. PMID 15057822.  Missing |last21= in Authors list (help)
  6. ^ Drosophila 12 Genomes, Consortium; Clark, A. G.; Eisen, M. B.; Smith, D. R.; Bergman, C. M.; Oliver, B; Markow, T. A.; Kaufman, T. C.; Kellis, M; Gelbart, W; Iyer, V. N.; Pollard, D. A.; Sackton, T. B.; Larracuente, A. M.; Singh, N. D.; Abad, J. P.; Abt, D. N.; Adryan, B; Aguade, M; Akashi, H; Anderson, W. W.; Aquadro, C. F.; Ardell, D. H.; Arguello, R; Artieri, C. G.; Barbash, D. A.; Barker, D; Barsanti, P; Batterham, P et al. (2007). "Evolution of genes and genomes on the Drosophila phylogeny". Nature 450 (7167): 203–18. doi:10.1038/nature06341. PMID 17994087. 
  7. ^ "Prof. Chris P Ponting BA MSc DPhil". Retrieved 28 August 2009. 
  8. ^ Lander, E. S.; Linton, M.; Birren, B.; Nusbaum, C.; Zody, C.; Baldwin, J.; Devon, K.; Dewar, K.; Doyle, M.; Fitzhugh, W.; Funke, R.; Gage, D.; Harris, K.; Heaford, A.; Howland, J.; Kann, L.; Lehoczky, J.; Levine, R.; McEwan, P.; McKernan, K.; Meldrim, J.; Mesirov, J. P.; Miranda, C.; Morris, W.; Naylor, J.; Raymond, C.; Rosetti, M.; Santos, R.; Sheridan, A. et al. (Feb 2001). "Initial sequencing and analysis of the human genome". Nature 409 (6822): 860–921. doi:10.1038/35057062. ISSN 0028-0836. PMID 11237011. 
  9. ^ Chinwalla, A. T.; Waterston, L. L.; Lindblad-Toh, K. D.; Birney, G. A.; Rogers, L. A.; Abril, R. S.; Agarwal, T. A.; Agarwala, L. W.; Ainscough, E. R.; Alexandersson, J. D.; An, T. L.; Antonarakis, W. E.; Attwood, J. O.; Baertsch, M. N.; Bailey, K. H.; Barlow, C. S.; Beck, T. C.; Berry, B.; Birren, J.; Bloom, E.; Bork, R. H.; Botcherby, M. C.; Bray, R. K.; Brent, S. P.; Brown, P.; Brown, E.; Bult, B.; Burton, T.; Butler, D. G.; Campbell, J. (2002). "Initial sequencing and comparative analysis of the mouse genome". Nature 420 (6915): 520–562. doi:10.1038/nature01262. PMID 12466850. 
  10. ^ Amos, Jonathan (31 March 2004). "Rat's 'life code' read by science". BBC News. Retrieved 19 December 2008. 
  11. ^ "Chicken gives up genetic secrets". BBC News. 9 December 2004. Retrieved 19 December 2008. 
  12. ^ Lindblad-Toh, K.; Wade, C. M.; Mikkelsen, T. S.; Karlsson, E. K.; Jaffe, D. B.; Kamal, M.; Clamp, M.; Chang, J. L.; Kulbokas, E. J.; Zody, M. C.; Mauceli, E.; Xie, X.; Breen, M.; Wayne, R. K.; Ostrander, E. A.; Ponting, C. P.; Galibert, F.; Smith, D. R.; Dejong, P. J.; Kirkness, E.; Alvarez, P.; Biagi, T.; Brockman, W.; Butler, J.; Chin, C. W.; Cook, A.; Cuff, J.; Daly, M. J.; Decaprio, D.; Gnerre, S. (2005). "Genome sequence, comparative analysis and haplotype structure of the domestic dog". Nature 438 (7069): 803–819. doi:10.1038/nature04338. PMID 16341006.  edit
  13. ^ Mikkelsen, T. S.; Wakefield, M. J.; Aken, B.; Amemiya, C. T.; Chang, J. L.; Duke, S.; Garber, M.; Gentles, A. J.; Goodstadt, L.; Heger, A.; Jurka, J.; Kamal, M.; Mauceli, E.; Searle, S. M. J.; Sharpe, T.; Baker, M. L.; Batzer, M. A.; Benos, P. V.; Belov, K.; Clamp, M.; Cook, A.; Cuff, J.; Das, R.; Davidow, L.; Deakin, J. E.; Fazzari, M. J.; Glass, J. L.; Grabherr, M.; Greally, J. M.; Gu, W. (2007). "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences". Nature 447 (7141): 167–177. doi:10.1038/nature05805. PMID 17495919. 
  14. ^ Warren, W. C.; Hillier, L. W.; Marshall Graves, J. A.; Birney, E.; Ponting, C. P.; Grützner, F.; Belov, K.; Miller, W.; Clarke, L.; Chinwalla, A. T.; Yang, S. P.; Heger, A.; Locke, D. P.; Miethke, P.; Waters, P. D.; Veyrunes, F. D. R.; Fulton, L.; Fulton, B.; Graves, T.; Wallis, J.; Puente, X. S.; López-Otín, C.; Ordóñez, G. R.; Eichler, E. E.; Chen, L.; Cheng, Z.; Deakin, J. E.; Alsop, A.; Thompson, K.; Kirby, P. (2008). "Genome analysis of the platypus reveals unique signatures of evolution". Nature 453 (7192): 175–183. doi:10.1038/nature06936. PMC 2803040. PMID 18464734.  edit
  15. ^ Discussing the platypus genome
  16. ^ Briggs, Helen (7 May 2008). "Platypus genetic code unravelled". BBC News. Retrieved 19 December 2008. 
  17. ^ Jenuwein, T.; Eisenhaber, S.; O'Carroll, F.; Strahl, D. N.; Sun, B. D.; Schmid, Z. W.; Opravil, M.; Mechtler, S.; Ponting, K.; Allis, C. P.; Jenuwein, C. D. (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases". Nature 406 (6796): 593–599. doi:10.1038/35020506. PMID 10949293.  edit
  18. ^ Zhang, Y.; Leaves, N. I.; Anderson, G. G.; Ponting, C. P.; Broxholme, J.; Holt, R.; Edser, P.; Bhattacharyya, S.; Dunham, A.; Adcock, I. M.; Pulleyn, L.; Barnes, P. J.; Harper, J. I.; Abecasis, G. A.; Cardon, L.; White, M.; Burton, J.; Matthews, L.; Mott, R.; Ross, M.; Cox, R.; Moffatt, M. F.; Cookson, W. O. C. M. (2003). "Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma". Nature Genetics 34 (2): 181–186. doi:10.1038/ng1166. PMID 12754510. 
  19. ^ Gerken, T.; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. J. (2007). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science 318 (5855): 1469–1472. doi:10.1126/science.1151710. PMC 2668859. PMID 17991826.  edit
  20. ^ Ponting, C. P.; Hutton, M.; Nyborg, A.; Baker, M.; Jansen, K.; Golde, T. E. (2002). "Identification of a novel family of presenilin homologues". Human Molecular Genetics 11 (9): 1037–1044. doi:10.1093/hmg/11.9.1037. PMID 11978763. 
  21. ^ Abd El-Aziz, M. M.; Barragan, I.; O'Driscoll, C. A.; Goodstadt, L.; Prigmore, E.; Borrego, S.; Mena, M.; Pieras, J. I.; El-Ashry, M. F.; Safieh, L. A.; Shah, A.; Cheetham, M. E.; Carter, N. P.; Chakarova, C.; Ponting, C. P.; Bhattacharya, S. S.; Antinolo, G. (2008). "EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa". Nature Genetics 40 (11): 1285–1287. doi:10.1038/ng.241. PMC 2719291. PMID 18836446.  edit
  22. ^ Dickens, N. J.; Beatson, S.; Ponting, C. P. (2002). "Cadherin-like domains in α-dystroglycan, α/ε-sarcoglycan and yeast and bacterial proteins". Current Biology 12 (6): R197–R199. doi:10.1016/S0960-9822(02)00748-0. PMID 11909544. 
  23. ^ Crow, Y. J.; Leitch, A.; Hayward, B. E.; Garner, A.; Parmar, R.; Griffith, E.; Ali, M.; Semple, C.; Aicardi, J.; Babul-Hirji, R.; Baumann, C.; Baxter, P.; Bertini, E.; Chandler, K. E.; Chitayat, D.; Cau, D.; Déry, C.; Fazzi, E.; Goizet, C.; King, M. D.; Klepper, J.; Lacombe, D.; Lanzi, G.; Lyall, H.; Martínez-Frías, M. A. L.; Mathieu, M. L.; McKeown, C.; Monier, A.; Oade, Y.; Quarrell, O. W. (2006). "Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection". Nature Genetics 38 (8): 910–916. doi:10.1038/ng1842. PMID 16845400.