Slade received his highest exposure in November 1989 when he was asked to join the Australian hard rock band AC/DC after their then-drummer Simon Wright had departed. AC/DC were signed to the same management company as Gary Moore who Slade had just finished touring with. The Young brothers (Angus and Malcolm) initially hired Slade only temporarily through management, then asked him during the recording of the only album he made with them, to join the band. Slade played on The Razors Edge album in 1990 and the accompanying world tour, and the "Big Gun" single released in 1993. According to Slade, after working on demos for the following album, Ballbreaker, Malcolm Young called Slade and told him they wanted to try a reunion with former drummer Phil Rudd. Slade replied, "That's me out then, I'm gone." Young said that he wanted to keep Slade on hand if Rudd's return did not work out, but Slade refused. However, he had made statements that he still got on well with AC/DC and "it was an honour and a privilege to play with those guys".
After his departure, Slade spent a few years living in the UK countryside before receiving a call from Geoff Downes from the British progressive rock group Asia. Slade was with Asia for six years, before departing in September 2005.
Slade has fronted an AC/DC tribute band called Chris Slade Steel Circle, and also tours with The Chris Slade Timeline – a band formed to celebrate 50 years as a rock drummer. The band takes music from all aspects of his lengthy career.
On 7 February 2015, Slade confirmed on his Facebook page that the AC/DC drum stool is "under old management." The next day, he performed with AC/DC at the Grammys. Additionally, Slade will serve as the band's drummer for the duration of their 2015 tour.