Nasse was a member of the somatic school of psychiatry that was popular during the first half of the 19th century in Germany. He believed that diagnosis and treatment of mental disorders depended on investigation of the somatic activity of a patient, formulating his belief system on the basis that physical disease produced a disturbance in the relationship between the psyche and the soma. He was interested in the works of Johann Friedrich Herbart (1776–1841), and skeptical of natural philosophers. Nasse is credited for introducing the practical experience of "bedside diagnosis" into the university lecture hall. Nasse died on his birthday, aged 73 in Marburg.
His name is associated with "Nasse's law", a dictum that states that hemophilia occurs only in males but is transmitted through females. Law formulated by Nasse in 1820.
In 1818 he founded a journal for psychiatrists called Zeitschrift für psychische Ärzte (later renamed Jahrbücher für Anthropologie). In addition, with Carl Wigand Maximilian Jacobi (1775–1858), he published a short-lived journal titled Zeitschrift für Heilung und Beurtheilung krankhafter Seelenstörungen (Journal for the healing and diagnosis of pathological mental disorders). The following are a few of his principal writngs:
Handbuch der speciellen Therapie, (1826–28)
Handbuch der allgemeinen Therapie, (1840)
Vermischte Schriften psychologischen und physiologischen Inhalts, (1850)
Untersuchungen zur Physiologie und Patholoqie, (1835–39)