chromodomain ( chromatin organization modifier ) is a [2 ] protein structural domain of about 40-50 amino acid residues commonly found in proteins associated with the remodeling and manipulation of chromatin. The domain is highly conserved among both plants and animals, and is represented in a large number of different proteins in many genomes, such as that of the mouse. Some chromodomain-containing genes have multiple alternative splicing isoforms that omit the chromodomain entirely. In [3 ] mammals, chromodomain-containing proteins are responsible for aspects of gene regulation related to chromatin remodeling and formation of heterochromatin regions. Chromodomain-containing proteins also bind [4 ] methylated histones [5 ] and appear in the [6 ] RNA-induced transcriptional silencing complex. [7 ]
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References [ edit ]
^ Min J, Zhang Y, Xu RM (August 2003). "Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27". Genes Dev. 17 (15): 1823–8. doi: 10.1101/gad.269603. PMC 196225. PMID 12897052.
^ Messmer S, Franke A, Paro R (July 1992). "Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster". Genes Dev. 6 (7): 1241–1254. doi: 10.1101/gad.6.7.1241. PMID 1628830.
^ Tajul-Arifin K, Teasdale R, Ravasi T, Hume DA, Mattick JS (2003). "Identification and Analysis of Chromodomain-Containing Proteins Encoded in the Mouse Transcriptome". Genome Res 13 (6B): 1416–1429. doi: 10.1101/gr.1015703. PMC 403676. PMID 12819141.
^ Jones DO, Cowell IG, Singh PB (2000). "Mammalian chromodomain proteins: their role in genome organisation and expression". Bioessays 22 (2): 124–37. doi: 10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E. PMID 10655032.
^ Nielsen PR, Nietlispach D, Mott HR, Callaghan J, Bannister A, Kouzarides T et al. (2002). "Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9". Nature 416 (6876): 103–7. doi: 10.1038/nature722. PMID 11882902.
^ Jacobs SA, Khorasanizadeh S (2002). "Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail". Science 295 (5562): 2080–3. doi: 10.1126/science.1069473. PMID 11859155.
^ Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal SI et al. (2004). "RNAi-Mediated Targeting of Heterochromatin by the RITS Complex". Science 303 (5658): 672–6. doi: 10.1126/science.1093686. PMC 3244756. PMID 14704433.
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