A chromophobe is a histological structure that does not stain readily, and thus appears relatively pale under the microscope—hence their "fear" ("phobia") of "color" ("chrome").
Chromophobe cells are one of three cell types, the others being basophils and acidophils. One type of chromophobe cell is known as amphophils. Amphophils are epithelial cells found in the anterior and intermediate lobes of the pituitary. Together, these epithelial cells are responsible for producing the hormones of the anterior pituitary and releasing them into the bloodstream. Melanotrophs (also, Melanotropes) are another type of chromophobe which secrete melanocyte stimulating hormone (MSH).