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Chronic fatigue may refer to:
- Chronic fatigue, a long-term state of physical or mental exhaustion, a symptom of many chronic illnesses
- Chronic fatigue syndrome, an illness of unknown cause comprising post-exertional malaise, unrefreshing sleep, widespread muscle and joint pain, sore throat, cognitive difficulties, and chronic, often severe, mental and physical exhaustion, for a minimum of six months, not due to ongoing exertion, not substantially relieved by rest, and not due to any other medical condition
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