Chymase

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chymase 1, mast cell
1KLT.png
Chymase with PMSF bound PDB: 1KLT
Identifiers
Symbol CMA1
Entrez 1215
HUGO 2097
OMIM 118938
RefSeq NM_001836
UniProt P23946
Other data
Locus Chr. 14 q11.2

Chymases (EC 3.4.21.39, mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease) are a family of serine proteases found primarily in mast cells, though also present in basophil granulocytes (e.g. alpha chymase mcpt8). They show broad peptidolytic activity and are involved in a variety of functions. For example, chymases are released by mucosal mast cells upon challenge with parasites and parasite antigens promoting an inflammatory response. Chymases are also known to convert angiotensin I to angiotensin II and thus play a role in hypertension and atherosclerosis.[1]

Because of its role in inflammation it has been investigated as a target in the treatment of asthma.[2]

References[edit]

  1. ^ Caughey, GH. Mast cell tryptases and chymases in inflammation and host defense. Immu Revs 2007 (217): 141-154. PMID 17498057
  2. ^ de Garavilla et al. Journal of Biochemistry 2005(280) pp.18001-18007.