Cicletanine
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| Systematic (IUPAC) name | |
| 3-(4-Chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Routes | Oral |
| Pharmacokinetic data | |
| Protein binding | 97.3% |
| Half-life | 7.9 h |
| Identifiers | |
| CAS number | 89943-82-8 |
| ATC code | C03BX03 |
| PubChem | CID 54910 |
| ChemSpider | 49583  |
| UNII | CHG7QC509W |
| KEGG | D03487 |
| ChEMBL | CHEMBL191886 |
| Chemical data | |
| Formula | C14H12ClNO2 |
| Mol. mass | 261.703 g/mol |
| SMILES | eMolecules & PubChem |
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Cicletanine is a furopyridine low-ceiling diuretic drug, usually used in the treatment of hypertension.[1] The drug is manufactured by Ipsen and marketed by Recordati (in France) under the trade name Tenstaten.
It appears to be more potent in salt-sensitive hypertension.[2]
[edit] Mechanism
It can inhibit protein kinase C.[3]
[edit] References
- ^ Jean Sassard (1992). Genetic Hypertension. John Libbey Eurotext. ISBN 9780861963133. http://books.google.com/?id=v4E_g_D6xCwC&pg=PA547&lpg=PA547&dq=Cicletanine
- ^ Bagrov AY, Dmitrieva RI, Dorofeeva NA et al (February 2000). "Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism". J. Hypertens. 18 (2): 209–15. doi:10.1097/00004872-200018020-00012. PMID 10694190. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0263-6352&volume=18&issue=2&spage=209.
- ^ Fedorova OV, Talan MI, Agalakova NI, Droy-Lefaix MT, Lakatta EG, Bagrov AY (March 2003). "Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension". Hypertension 41 (3): 505–11. doi:10.1161/01.HYP.0000053446.43894.9F. PMID 12623951. http://hyper.ahajournals.org/cgi/pmidlookup?view=long&pmid=12623951.
[edit] External links
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