Ciclotizolam

Ciclotizolam
Systematic (IUPAC) name
	2-Bromo-4-(o-chlorophenyl)-9-cyclohexyl-6H-thieno(3,2-f)-s-triazolo(4,3-a)(1,4)diazepine
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	58765-21-2
ATC code	None
PubChem	CID 71949
ChemSpider	64956
UNII	JK517QTN4Q
Chemical data
Formula	C20H18BrClN4S
Mol. mass	461.806
	SMILES Clc5ccccc5C/2=N/Cc1nnc(n1c3sc(Br)cc\23)C4CCCCC4;
	InChI InChI=1S/C20H18BrClN4S/c21-16-10-14-18(13-8-4-5-9-15(13)22)23-11-17-24-25-19(26(17)20(14)27-16)12-6-2-1-3-7-12/h4-5,8-10,12H,1-3,6-7,11H2 ; Key:ZOSHXIXUCKESEG-UHFFFAOYSA-N ;
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Ciclotizolam^[1] (WE-973) is a drug which is a thienobenzodiazepine derivative. It is a partial agonist for the benzodiazepine site of the GABA_A receptor, with similar binding affinity to related compounds like brotizolam, but a low efficacy.^[2]^[3]

References [edit]

^ DE Patent 2445430
^ Weber KH, Kuhn FJ, Böke-Kuhn K, Lehr E, Danneberg PB, Hommer D, Paul SM, Skolnick P (February 1985). "Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines')". European Journal of Pharmacology 109 (1): 19–31. doi:10.1016/0014-2999(85)90535-7. PMID 2986988.
^ Ikeda M, Weber KH, Bechtel WD, Malatynska E, Yamamura HI (1989). "Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles". Life Sciences 45 (4): 349–58. doi:10.1016/0024-3205(89)90145-8. PMID 2569655.

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