Ciclotizolam

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Ciclotizolam
Ciclotizolam.png
Systematic (IUPAC) name
2-Bromo-4-(o-chlorophenyl)-9-cyclohexyl-6H-thieno(3,2-f)-s-triazolo(4,3-a)(1,4)diazepine
Clinical data
Legal status ?
Identifiers
CAS number 58765-21-2 YesY
ATC code None
PubChem CID 71949
ChemSpider 64956 YesY
UNII JK517QTN4Q YesY
ChEMBL CHEMBL2105986
Chemical data
Formula C20H18BrClN4S 
Mol. mass 461.806
 YesY (what is this?)  (verify)

Ciclotizolam[1] (WE-973) is a drug which is a thienobenzodiazepine derivative. It is a partial agonist for the benzodiazepine site of the GABAA receptor, with similar binding affinity to related compounds like brotizolam, but a low efficacy.[2][3]

See also[edit]

References[edit]

  1. ^ DE Patent 2445430
  2. ^ Weber KH, Kuhn FJ, Böke-Kuhn K, Lehr E, Danneberg PB, Hommer D, Paul SM, Skolnick P (February 1985). "Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines')". European Journal of Pharmacology 109 (1): 19–31. doi:10.1016/0014-2999(85)90535-7. PMID 2986988. 
  3. ^ Ikeda M, Weber KH, Bechtel WD, Malatynska E, Yamamura HI (1989). "Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles". Life Sciences 45 (4): 349–58. doi:10.1016/0024-3205(89)90145-8. PMID 2569655.