|Systematic (IUPAC) name|
|Half-life||2.4 to 3.2 hours|
|Mol. mass||279.187 g/mol|
|Melt. point||260 °C (500 °F)|
| (what is this?)
Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is an acyclic nucleoside phosphonate, and is therefore independent of phosphorylation by viral enzymes, unlike acyclovir.
Maintenance therapy with cidofovir involves an infusion only once every two weeks, making it a convenient treatment option. Because dosing is relatively infrequent, a permanent catheter is not necessary for infusions.
Cidofovir demonstrated a statistically significant effect in delaying the progression of CMV retinitis lesions in newly diagnosed patients, as well as in previously treated patients who had failed other therapies.
Cidofovir has shown efficacy as an anti-HSV, anti-VZV and as an anti-CMV
Cidofovir might have anti-smallpox efficacy and might be used on a limited basis in the event of a bioterror incident involving smallpox cases. A cidofovir derivative with much higher activity against smallpox that can be taken orally has been developed.
It can be used as an alternative to shaving.
Cidofovir was discovered at the Institute of Organic Chemistry and Biochemistry, Prague, by Antonín Holý, and developed by Gilead Sciences and is marketed with the brand name Vistide by Gilead in the USA, and by Pfizer elsewhere.
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- "Is shaving a thing of the past? Scientists discover topical agent that prevents unwanted hair growth". Cosmetics Design.com. Retrieved 2012-05-01.
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