Ciladopa

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Ciladopa
Ciladopa.png
Systematic (IUPAC) name
2-{4-[(2S)-2-(3,4-dimethoxyphenyl)-2-hydroxyethyl]piperazin-1-yl}cyclohepta-2,4,6-trien-1-one
Clinical data
Legal status Uncontrolled
Routes Oral
Identifiers
CAS number 80109-27-9
ATC code None
PubChem CID 133371
ChemSpider 117659
UNII D09L486R3J YesY
ChEMBL CHEMBL2110793
Chemical data
Formula C21H26N2O4 
Mol. mass 370.44 g/mol

Ciladopa (AY-27,110) is a dopamine agonist with a similar chemical structure to dopamine.[1] It was under investigation as an antiparkinsonian agent but was discontinued due to concerns of tumorogenesis in rodents.[2][3][4][5]

References[edit]

  1. ^ Voith K (1985). "The comparative long-term effects of ciladopa (AY-27,110), a chemically novel dopaminergic agonist, in 6-OHDA-lesioned and intact rats". Psychopharmacology 85 (4): 405–9. doi:10.1007/BF00429654. PMID 3927334. 
  2. ^ Koller WC, Fields JZ, Gordon JH, Perlow MJ (September 1986). "Evaluation of ciladopa hydrochloride as a potential anti-Parkinson drug". Neuropharmacology 25 (9): 973–9. doi:10.1016/0028-3908(86)90190-5. PMID 3774130. 
  3. ^ Weiner WJ, Factor SA, Sanchez-Ramos J, Berger J (1987). "A double-blind evaluation of ciladopa in Parkinson's disease". Movement Disorders : Official Journal of the Movement Disorder Society 2 (3): 211–7. doi:10.1002/mds.870020308. PMID 3332914. 
  4. ^ Lieberman A, Gopinathan G, Neophytides A, Pasternack P, Goldstein M (May 1987). "Advanced Parkinson's disease: use of partial dopamine agonist, ciladopa". Neurology 37 (5): 863–5. doi:10.1212/wnl.37.5.863. PMID 3574692. 
  5. ^ Lang AE (August 1987). "Update on dopamine agonists in Parkinson's disease: "beyond bromocriptine"". The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques 14 (3 Suppl): 474–82. PMID 3315148.