Cilastatin

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Cilastatin
Cilastatin.svg
Cilastatin ball-and-stick.png
Systematic (IUPAC) name
(Z)-7-[(2R)-2-Amino-3-hydroxy-3-oxopropyl]sulfanyl-2-{[(1S)-2,2-dimethylcyclopropanecarbonyl]amino}hept-2-enoic acid
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a686013
Legal status
?
Routes IV
Identifiers
CAS number 82009-34-5 YesY
ATC code J01DH51 (combination with imipenem)
PubChem CID 5280454
DrugBank DB01597
ChemSpider 4940183 YesY
UNII 141A6AMN38 YesY
KEGG D07698 YesY
ChEBI CHEBI:3697 YesY
ChEMBL CHEMBL766 YesY
Chemical data
Formula C16H26N2O5S 
Mol. mass 358.454 g/mol
 YesY (what is this?)  (verify)

Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase.[1]

Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Imipenem alone is an effective antibiotic and can be given without the cilastatin. Cilastatin itself does not have antibiotic activity.

Another carbapenem, meropenem is resistant to dehydropeptidase; therefore, it can be given without cilastatin.

See also[edit]

References[edit]

  1. ^ Keynan S, Hooper NM, Felici A, Amicosante G, Turner AJ (1995). "The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA". Antimicrob. Agents Chemother. 39 (7): 1629–31. doi:10.1128/aac.39.7.1629. PMC 162797. PMID 7492120.