Cinchophen
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| Systematic (IUPAC) name | |
| 2-phenylquinoline-4-carboxylic acid | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 132-60-5 |
| ATC code | M04AC02 |
| PubChem | CID 8593 |
| ChemSpider | 8274  |
| UNII | 39Y533Z02M |
| KEGG | D07280 |
| ChEMBL | CHEMBL348000 |
| Chemical data | |
| Formula | C16H11NO2 |
| Mol. mass | 249.264 g/mol |
| SMILES | eMolecules & PubChem |
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Cinchophen (trade names Atophan, Quinophan, and Phenaquin) is an analgesic drug that was introduced in 1910 and frequently used to treat gout. This drug is still used, in combination with Prednisolone, by veterinarians to treat arthritis in animals.
Use of this drug in humans ceased in the 1930s due to the discovery that cinchophen can cause serious liver damage.[1]
There is some evidence that it stimulates C-Fos.[2]
[edit] References
- ^ Cutrín Prieto C, Nieto Pol E, Batalla Eiras A, Casal Iglesias L, Pérez Becerra E, Lorenzo Zúñiga V (1991). "[Toxic hepatitis from cinchophen: report of 3 cases]" (in Spanish; Castilian). Medicina clínica 97 (3): 104–6. PMID 1679861.
- ^ Takayama K, Xiong Y, Miura M (May 1994). "Neuronal expression of Fos protein in the paraventricular nucleus of the hypothalamus after i.p. injection of ulcergenic cinchophen". Neurosci. Lett. 172 (1–2): 55–8. doi:10.1016/0304-3940(94)90661-0. PMID 7916144. http://linkinghub.elsevier.com/retrieve/pii/0304-3940(94)90661-0.
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