From Wikipedia, the free encyclopedia
Jump to: navigation, search
Systematic (IUPAC) name
Clinical data
Routes of
CAS Registry Number 63269-31-8 YesY
ATC code None
PubChem CID: 44463
ChemSpider 40461 YesY
KEGG D03523 YesY
Synonyms Ciramadol, WY-15705
Chemical data
Formula C15H23NO2
Molecular mass 249.349 g/mol
 YesY (what is this?)  (verify)

Ciramadol (WY-15,705) is an opioid analgesic that was developed in the late 1970s[1] and is related to phencyclidine, tramadol, tapentadol and venlafaxine.[2] It is a mixed agonist-antagonist for the μ-opioid receptor with relatively low abuse potential[3] and a ceiling on respiratory depression[4] which makes it a relatively safe drug. It has a slightly higher potency and effectiveness as an analgesic than codeine,[5] but is weaker than morphine.[6] Other side effects include sedation and nausea but these are generally less severe than with other similar drugs.[7]

See also[edit]


  1. ^ US Patent 3928626 - Benzylamine Analgesics
  2. ^ Cochrane AD, Bell R, Sullivan JR, Shaw J. Ciramadol. A new analgesic. Medical Journal of Australia. 1979 Nov 3;2(9):501-2.
  3. ^ Preston KL, Bigelow GE, Liebson IA. Comparative evaluation of morphine, pentazocine and ciramadol in postaddicts. Journal of Pharmacology and Experimental Therapeutics. 1987 Mar;240(3):900-10.
  4. ^ Romagnoli A, Keats AS. Low ceiling respiratory depression by ciramadol. International Journal of Clinical Pharmacology Research. 1986;6(6):451-5.
  5. ^ Downing JW, Brock-Utne JG, Holloway AM. Ciramadol - a new synthetic analgesic. A double-blind comparison with oral codeine for postoperative pain relief. South African Medical Journal. 1983 Dec 10;64(25):978-82.
  6. ^ Powell WF. A double-blind comparison of multiple intramuscular doses of ciramadol, morphine, and placebo for the treatment of postoperative pain. Anesthesia and Analgesia. 1985 Nov;64(11):1101-7.
  7. ^ Stambaugh JE Jr, McAdams J. Comparison of the analgesic efficacy and safety oral ciramadol, codeine, and placebo in patients with chronic cancer pain. Journal of Clinical Pharmacology. 1987 Feb;27(2):162-6.