Cirazoline

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Cirazoline
Cirazoline.png
Identifiers
CAS number 59939-16-1
PubChem 2765
ChemSpider 2663 YesY
MeSH cirazoline
ChEMBL CHEMBL13852 YesY
IUPHAR ligand 515
Jmol-3D images Image 1
Properties
Molecular formula C13H16N2O
Molar mass 216.279
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

Cirazoline is a nonselective agonist of the alpha-1 adrenergic receptor (α1-AR), and an antagonist to the alpha-2 adrenergic receptor.[1] However, it is somewhat sub-type specific to the α1-AR as it is only a partial agonist at the alpha-1B adrenergic receptor (α1B-AR) and alpha-1D adrenergic receptor (α1D-AR), but a full agonist at the alpha-1A adrenergic receptor (α1A-AR).[2] It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent.[1]

Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of α1-adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain.[3]

References[edit]

  1. ^ a b Ruffolo, R. R. Jr.; Waddell, J. E. (1982). "Receptor interactions of imidazolines. IX. Cirazoline is an α1 adrenergic agonist and an α2 adrenergic antagonist". Journal of Pharmacology and Experimental Therapeutics 222 (1): 29–36. PMID 6123592. 
  2. ^ Horie, K; Obika, K; Foglar, R. (1995). "Selectivity of the imidazoline α-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned α1-adrenoceptor subtypes". British Journal of Pharmacology 116 (1): 1611–8. doi:10.1111/j.1476-5381.1995.tb16381.x. PMID 8564227. 
  3. ^ Davies, B. T.; Wellman, P. J. (1992). "Effects on ingestive behavior in rats of the α1-adrenoceptor agonist cirazoline". European Journal of Pharmacology 210 (1): 11–16. doi:10.1016/0014-2999(92)90645-K. PMID 1350985.