||This article needs more medical references for verification or relies too heavily on primary sources. (July 2012)|
Cissus quadrangularis is a perennial plant of the grape family. It is commonly known as Veldt Grape or Devil's Backbone.
It is probably native to India or Sri Lanka, but is also found in Africa, Arabia, and Southeast Asia. It has been imported to Brazil and the southern United States. It is very commonly known as asthisamharaka. Cissus has been used in various ayurvedic classical medicines to heal broken bones and injured ligaments and tendons.
Cissus quadrangularis reaches a height of 1.5 m and has quadrangular-sectioned branches with internodes 8 to 10 cm long and 1.2 to 1.5 cm wide. Along each angle is a leathery edge. Toothed trilobe leaves 2 to 5 cm wide appear at the nodes. Each has a tendril emerging from the opposite side of the node. Racemes of small white, yellowish, or greenish flowers; globular berries are red when ripe.
Cissus quadrangularis has been used as a medicinal plant since antiquity. In siddha medicine it is considered a tonic and analgesic, and is believed to help heal broken bones, thus its name asthisamharaka (that which prevents the destruction of bones). It is said to have antibacterial, antifungal, antioxidant, anthelmintic, antihemorrhoidal and analgesic activities. It has been found to contain a rich source of carotenoids, triterpenoids and ascorbic acid. Its bactericidal effects on Helicobacter pylori hold promise as a potential treatment of gastric ulcers in conjunction with NSAID therapy. A weight loss supplement containing Cissus quadrangularis and other ingredients including green tea, soy, selenium, chromium, and B vitamins was evaluated in an 8-week trial. The supplement helped reduce body weight by 4-8% ( placebo 2.4%) a clinically significant weight loss.
A study was undertaken to evaluate the effect of methanolic extract of Cissus quadrangularis L. (CQ) on the healing process of experimentally fractured radius-ulna of dog. CQ treated animals revealed faster initiation of healing process than the control animals on radiological and histopathological examinations. The treated group also revealed a decrease in serum calcium level to a greater extent than the control group. Healing was almost complete on 21st day of fracture in the treated animals and remained incomplete in the control animals. No significant alteration of serum calcium level was observed on 21 st day of fracture in both the groups.
A paper published in the World Journal of Gastroenterology in October 2010, on conflicts of interest in alternative weight loss product research, noted that at least three studies supported the safety and effectiveness of CQ for weight loss, but "lack financial disclosures or funding sources, beyond mentioning that the CQ being tested was provided by" General Health Alliances, an herbal products manufacturer. The studies did not disclose that one of its authors was a chief scientific officer for GHA that holds a patent on a CQ product.
- Cissus succulenta (Galpin) Burtt Davy
- Cissus tetragona Harv.
- Vitis quadrangularis (L.) Wall. ex Wight & Arn.
- Vitis succulenta Galpin
|Wikimedia Commons has media related to Cissus quadrangularis.|
- Pharmacological and therapeutic activity of Cissus quadrangularis: An overview Mishra G., Srivastava S., Nagori B.P. International Journal of PharmTech Research 2010 2:2 (1298-1310)
- In vitro and In vivo evaluation of free radical scavenging potential of Cissus quadrangularis, Mallika Jainu1 and C.S. Shyamala Devi, African Journal of Biomedical Research, Vol. 8 (2005); 95 - 99, http://www.ajol.info/index.php/ajbr/article/viewFile/35768/59535
- Protective effect of Cissus quadrangularis on neutrophil mediated tissue injury induced by aspirin in rats
- Greenway, FL; Bray, GA (2010). "Combination drugs for treating obesity". Current Diabetes Reports 10 (2): 108–15. doi:10.1007/s11892-010-0096-4. PMID 20425569.
- Indian Journal of Pharmacology 1994; 26: 44 - 45
- D.K. DEKA, L.C. LAHON, J. SAIKIA** A. MUKIT***Departments of Pharmacology_and Toxicology, Surgery and Radiology and Veterinary Pathology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati - 781 022
- Lobb, Anno (14 October 2010). "Science of weight loss supplements: Compromised by conflicts of interest?". World Journal of Gastroenterology 16 (38): 4880–4882. doi:10.3748/wjg.v16.i38.4880. PMC 2955261. PMID 20939120. Retrieved 31 March 2013.
- Total Synthesis of (±)-Quadrangularin A. Wenling Li, Hao Li, Ying Li and Zijie Hou, Angewandte Chemie International Edition, Volume 45, Issue 45, page 7609-7611, doi:10.1002/anie.200603097
- Sinónimos en Tropicos
- Cissus quadrangularis in West African plants – A Photo Guide.
- Austin, A. Jegadeesan, M. Gowrishankar, R. (2004) "Helicobactericidal Activity of Cissus quadrangularis L. Variant I"; Natural Product Sciences 10 (5): 217-219. Korean Society of Pharmacognosy.
- Chopra, SS, Patel, MR, Awadhiya, RP. (1976). "Studies of Cissus quadrangularis in experimental fracture repair: a histopathological study". Indian Journal of Medical Researches 64 (9): 1365–1368.
- Jainu, Mallika; Devi, Shyamala (2003). "Tent antiulcerogenic activity of methanolic extract of Cissus quadrangularis by antioxidative mechanism". Journal of Clinical Biochemistry and Nutrition 34 (2): 43–47. doi:10.3164/jcbn.34.43.
- Kashikar, ND; Indu, George (2006). "Antibacterial activity of Cissus quadrangularis Linn". Indian Journal of Pharmaceutical Sciences 68 (2): 245–247. doi:10.4103/0250-474X.25727.
- Oben, Julius; Damaris Mandob, Enyegue; Fomekong, Gilles I; Soukontoua, Yves B; Agbor, Gabriel A (2007). "The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress". Lipids in Health and Diseases 6: 4. doi:10.1186/1476-511X-6-4. PMC 1800848. PMID 17274828.
- Oben, Julius; Kuate, Dieudonne; Agbor, Gabriel; Momo, Claudia; Talla, Xavio (2006). "The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome". Lipids in Health and Diseases 5: 24. doi:10.1186/1476-511X-5-24. PMC 1570348. PMID 16948861.
- Analysis of the effect of Asthishrinkhla Kandaswarasa [stem juice of Cissus quadrangularis] in fracture healing in a rat model 'Dr. Deepanshu K. Mishra, Prof. Sanjeev Sharma, R.G.G.P.G. Ayu. College - Paprola' Prof. V.K. Gupta, Dr. G.C. Negi College of Vet. and Animal sciences - Palampur - Dec. 2010.