Cistrome

Cistrome This term http://cistrome.pbwiki.com was coined by investigators at the Dana-Farber Cancer Institute and Harvard Medical School to define the set of cis-acting targets (DNA binding sites) of a trans-acting factor (transcription factor, pioneer factor, restriction enzyme, etc.) on a genome scale. Technologies such as chromatin immunoprecipitation combined with microarray "ChIP-on-chip" or with massively parallel DNA sequencing "ChIP-Seq" have greatly facilitated the definition of the cistrome of transcription factors and other chromatin associated proteins.

References

• http://www.dana-farber.org/abo/news/press/2006/molecular-atlas-provides-new-tool-for-understanding-estrogen-fueled-breast-cancer.html

http://www.cell.com/content/article/abstract?uid=PIIS0092867408001189

http://erc.endocrinology-journals.org/cgi/content/full/16/2/381